• Publications
  • Influence
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
In young animals, monocular deprivation leads to an ocular dominance shift, whereas in adults after the critical period there is no such shift. Chondroitin sulphate proteoglycans (CSPGs) areExpand
  • 1,314
  • 136
  • PDF
Functional postnatal development of the rat primary visual cortex and the role of visual experience: Dark rearing and monocular deprivation
Postnatal development of rat visual cortical functions was studied by recording extracellularly from the primary visual cortex of 22 animals ranging in age from postnatal day 17 (P17) to P45. WeExpand
  • 631
  • 62
Perceptual learning specific for orientation and spatial frequency
Several examples of ‘perceptual learning’ (improvement of some perceptual task with practice) have been reported1–4. These studies are of great interest (for neurological research because theyExpand
  • 444
  • 24
Structural and functional recovery from early monocular deprivation in adult rats.
Visual deficits caused by abnormal visual experience during development are hard to recover in adult animals. Removal of chondroitin sulfate proteoglycans from the mature extracellular matrix withExpand
  • 343
  • 21
  • PDF
Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment
Neurogenesis continues to occur in the adult mammalian hippocampus and is regulated by both genetic and environmental factors. It is known that exposure to an enriched environment enhances the numberExpand
  • 484
  • 17
A re-evaluation of the mechanisms underlying simple cell orientation selectivity
Following from evidence supporting GABA as a putative inhibitory transmitter in the visual cortex, we have iontophoretically applied the GABA antagonist N-methyl bicuculline (Nmb) to simple cells inExpand
  • 282
  • 17
  • PDF
Environment and brain plasticity: towards an endogenous pharmacotherapy.
Brain plasticity refers to the remarkable property of cerebral neurons to change their structure and function in response to experience, a fundamental theoretical theme in the field of basic researchExpand
  • 230
  • 17
  • PDF
Acceleration of Visual System Development by Environmental Enrichment
Thus far, the developmental plasticity of the visual system has been studied by altering or reducing visual experience. Here, we investigated whether a complex sensory-motor stimulation, provided byExpand
  • 231
  • 15
  • PDF
Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity
Experience-dependent plasticity in the cortex is often higher during short critical periods in postnatal development. The mechanisms limiting adult cortical plasticity are still unclear. MaturationExpand
  • 277
  • 14
  • PDF
Learning in grating waveform discrimination: Specificity for orientation and spatial frequency
Abstract The effects of practice in the discrimination of briefly flashed gratings were investigated by a forced-choice procedure with error correction in a number of tasks requiring disciminationExpand
  • 258
  • 14