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Benzo[a]pyrene trans-7,8-Dihydrodiol

Known as: benzo(a)pyrene 7,8-dihydrodiol, (trans)-isomer, BPD, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene 
A polycyclic aromatic hydrocarbon and metabolite of benzo(a)pyrene with potent cytotoxic and mutagenic properties. Benzo(a)pyrene-trans-7,8… 
National Institutes of Health

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benzo(a)pyrene 7,8-dihydrodiol

Papers overview

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Highly Cited
2010
Highly Cited
2010
Shorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbons.
Shorter telomere length (TL) in peripheral blood lymphocytes (PBLs) is predictive of lung cancer risk. Polycyclic aromatic… 
Highly Cited
2004
Highly Cited
2004
Degradation of Benzo[a]pyrene by Mycobacterium vanbaalenii PYR-1
ABSTRACT Metabolism of the environmental pollutant benzo[a]pyrene in the bacterium Mycobacterium vanbaalenii PYR-1 was examined… 
Highly Cited
2004
Highly Cited
2004
Physiological characterization of Mycobacterium sp. strain 1B isolated from a bacterial culture able to degrade high‐molecular‐weight polycyclic aromatic hydrocarbons
Aim:  The aim of this study was to further characterize a bacterial culture (VUN 10,010) capable of benzo[a]pyrene cometabolism. 
Highly Cited
2000
Highly Cited
2000
Error-prone lesion bypass by human DNA polymerase eta.
DNA lesion bypass is an important cellular response to genomic damage during replication. Human DNA polymerase eta (Pol(eta… 
1995
1995
Differential mutagenicity and cytotoxicity of (±)‐benzo[a]pyrene‐trans‐7,8‐dihydrodiol and (±)‐anti‐benzo[a]pyrene‐trans‐7,8‐dihydrodiol‐9, 10‐epoxide in genetically engineered human fibroblasts
DNA repair–deficient (xeroderma pigmentosum group A (XPA)) and DNA repair‐proficient (normal) human skin fibroblasts were… 
Highly Cited
1989
Highly Cited
1989
Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.
A total of 57 procarcinogens was examined for induction of umu gene response in the chimeric plasmid pSK1002, carried in… 
Highly Cited
1983
Highly Cited
1983
Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells.
Cultured bronchial epithelial and fibroblastic cells from humans were used to study DNA damage and toxicity caused by… 
Highly Cited
1977
Highly Cited
1977
Marked differences in the tumor-initiating activity of optically pure (+)- and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene on mouse skin.
The ability of optically pure (+)- and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene to initiate skin tumors in mice was… 
Highly Cited
1976
Highly Cited
1976
(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice.
(+/-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]-pyrene, a known metabolite of benzo [a]pyrene, has been tested for carcinogenic… 
Highly Cited
1975
Highly Cited
1975
Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols.
The benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols (4-, 5-, 7-, 8-, 9-, and 10-hydroxybenzo[a… 
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