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Benzo[a]pyrene trans-7,8-Dihydrodiol
Known as:
benzo(a)pyrene 7,8-dihydrodiol, (trans)-isomer
, BPD
, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene
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A polycyclic aromatic hydrocarbon and metabolite of benzo(a)pyrene with potent cytotoxic and mutagenic properties. Benzo(a)pyrene-trans-7,8…
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National Institutes of Health
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1 relation
Broader (1)
benzo(a)pyrene 7,8-dihydrodiol
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Fatty Acid Hydroperoxides Support Cytochrome P450 2S1-Mediated Bioactivation of Benzo[a]pyrene-7,8-dihydrodiol
Peter H. Bui
,
E. Hsu
,
O. Hankinson
Molecular Pharmacology
2009
Corpus ID: 203871
In the accompanying report (p. 1031), we showed that a novel dioxin-inducible cytochrome P450, CYP2S1, efficiently metabolizes…
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2009
2009
Human papilloma virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53
Bo Chen
,
D. Simpson
,
+4 authors
W. Kaufmann
Cell Cycle
2009
Corpus ID: 32224113
After treatment with ultraviolet radiation (UV), human fibroblasts that express the HPV type 16 E6 oncoprotein display defects in…
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Highly Cited
2004
Highly Cited
2004
High DNA damage by benzo[a]pyrene 7,8-diol-9,10-epoxide in bronchial epithelial cells from patients with lung cancer: comparison with lung parenchyma.
M. Rojas
,
B. Marie
,
+5 authors
K. Alexandrov
Cancer Letters
2004
Corpus ID: 23596561
2001
2001
Effect of benzo[a]pyrene diol epoxide on expression of retinoic acid receptor-beta in immortalized esophageal epithelial cells and esophageal cancer cells.
Shumei Song
,
X. C. Xu
Biochemical and Biophysical Research…
2001
Corpus ID: 19984146
Expression of retinoic acid receptor-beta (RAR-beta) is frequently lost in tobacco-related cancers. Benzo[a]pyrene diol epoxide…
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1983
1983
Specificity of rat liver cytochrome P-450 isozymes in the mutagenic activation of benzo[a]pyrene, aromatic amines and aflatoxin B1.
I. Robertson
,
E. Zeiger
,
J. Goldstein
Carcinogenesis
1983
Corpus ID: 12925888
The ability of three purified forms of rat liver cytochrome P-450 to metabolically activate benzo[a]pyrene, trans-benzo-[a]pyrene…
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Highly Cited
1982
Highly Cited
1982
Inactivation of DNA-binding metabolites of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by glutathione and glutathione S-transferases.
S. Hesse
,
B. Jernström
,
M. Martínez
,
P. Moldéus
,
L. Christodoulides
,
B. Ketterer
Carcinogenesis
1982
Corpus ID: 30980214
The binding to DNA of reactive metabolites of trans-7,8-dihydro-7,8-dihydroxybenzo[a]pyrene (BP-7,8-diol) was studied following…
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1979
1979
Arachidonic acid‐dependent metabolism of (±) trans‐7,8‐dihydroxy‐7,8‐ dihydro‐benzo[a]pyrene (BP‐7,8 diol) to 7,10/8,9 tetrols
K. Sivarajah
,
H. Mukhtar
,
T. Eling
FEBS Letters
1979
Corpus ID: 39994904
1977
1977
Stereochemistry of the hydrolysis products and their acetonides of two stereoisomeric benzo[a]pyrene 7,8-diol 9,10-epoxides.
S. K. Yang
,
D. Mccourt
,
H. Gelboin
,
J. Miller
,
P. Roller
Journal of the American Chemical Society
1977
Corpus ID: 33023750
Highly Cited
1975
Highly Cited
1975
Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols.
A. Wood
,
R. L. Goode
,
+5 authors
D. Jerina
Proceedings of the National Academy of Sciences…
1975
Corpus ID: 25485112
The benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols (4-, 5-, 7-, 8-, 9-, and 10-hydroxybenzo[a…
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Highly Cited
1970
Highly Cited
1970
The relation of metabolism to macromolecular binding of the carcinogen benzo[a]pyrene, by mouse embryo cells in culture
M. Duncan
,
P. Brookes
International Journal of Cancer
1970
Corpus ID: 19241460
The metabolism of tritiated benzo[a]pyrene (B[a]P) by primary mouse embryo cells in culture was studied. At concentrations of B[a…
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