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Benzo[a]pyrene trans-7,8-Dihydrodiol

Known as: benzo(a)pyrene 7,8-dihydrodiol, (trans)-isomer, BPD, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene 
A polycyclic aromatic hydrocarbon and metabolite of benzo(a)pyrene with potent cytotoxic and mutagenic properties. Benzo(a)pyrene-trans-7,8… Expand
National Institutes of Health

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Broader (1)

benzo(a)pyrene 7,8-dihydrodiol

Papers overview

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Highly Cited
2013
Highly Cited
2013
Dose-response relationships of polycyclic aromatic hydrocarbons exposure and oxidative damage to DNA and lipid in coke oven workers.
Polycyclic aromatic hydrocarbons (PAHs) are known to induce reactive oxygen species and oxidative stress, but the dose-response… Expand
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2011
2011
The role of miR-506 in transformed 16HBE cells induced by anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide.
Growing evidence indicates that the alteration of microRNA (miRNA) expression in tumors that is induced by chemical carcinogens… Expand
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Highly Cited
2010
Highly Cited
2010
Shorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbons.
Shorter telomere length (TL) in peripheral blood lymphocytes (PBLs) is predictive of lung cancer risk. Polycyclic aromatic… Expand
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Highly Cited
2005
Highly Cited
2005
DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer.
BACKGROUND Interindividual differences in DNA repair capacity may influence cancer risk. We tested whether the nucleotide… Expand
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Highly Cited
2004
Highly Cited
2004
Degradation of Benzo[a]pyrene by Mycobacterium vanbaalenii PYR-1
ABSTRACT Metabolism of the environmental pollutant benzo[a]pyrene in the bacterium Mycobacterium vanbaalenii PYR-1 was examined… Expand
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Highly Cited
2000
Highly Cited
2000
Error-prone lesion bypass by human DNA polymerase eta.
DNA lesion bypass is an important cellular response to genomic damage during replication. Human DNA polymerase eta (Pol(eta… Expand
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Highly Cited
1997
Highly Cited
1997
Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis.
A mouse embryo culture model was used to determine whether embryonic prostaglandin H synthase (PHS)-catalyzed bioactivation and… Expand
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Highly Cited
1994
Highly Cited
1994
Identification of 1-hydroxypyrene glucuronide as a major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatography-mass spectrometry.
Humans are exposed to polycyclic aromatic hydrocarbons (PAHs) from various occupational, environmental, medicinal and dietary… Expand
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Highly Cited
1989
Highly Cited
1989
Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.
A total of 57 procarcinogens was examined for induction of umu gene response in the chimeric plasmid pSK1002, carried in… Expand
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Highly Cited
1983
Highly Cited
1983
Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells.
Cultured bronchial epithelial and fibroblastic cells from humans were used to study DNA damage and toxicity caused by… Expand
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