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- Publications
- Influence
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex.
- M. Lepourcelet, Ying-Nan Chen, +6 authors R. Shivdasani
- Medicine
- Cancer cell
- 2004
Key molecular lesions in colorectal and other cancers cause beta-catenin-dependent transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an opportunity for… Expand
Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex
- M. Lepourcelet, Ying-Nan Chen, +5 authors R. Shivdasani
- Biology
- 2004
Key molecular lesions in colorectal and other cancers cause beta-catenin-dependent transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an opportunity for… Expand
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.
- A. Kung, S. Zabludoff, +14 authors D. Livingston
- Biology, Medicine
- Cancer cell
- 1 July 2004
Homeostasis under hypoxic conditions is maintained through a coordinated transcriptional response mediated by the hypoxia-inducible factor (HIF) pathway and requires coactivation by the CBP and p300… Expand
Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes.
- A. Wood, D. Ryan, P. Thomas, W. Levin
- Medicine, Chemistry
- The Journal of biological chemistry
- 25 July 1983
High pressure liquid chromatographic systems capable of resolving at least 28 known and potential metabolites of 17 beta-hydroxy-4-androsten-3-one (testosterone) and 4-androstene-3,17-dione… Expand
Tumorigenicity of enantiomers of chrysene 1,2-dihydrodiol and of the diastereomeric bay-region chrysene 1,2-diol-3,4-epoxides on mouse skin and in newborn mice.
Abstract The tumorigenicity of chrysene, (+)- and (-)-trans-1,2-dihydroxy-1,2-dihydrochrysene (chrysene 1,2-dihydrodiol), and the (+)- and (-)-enantiomers of the diastereomeric bay-region chrysene… Expand
NMR strategy for unraveling structures of bioactive sponge-derived oxy-polyhalogenated diphenyl ethers.
- Laurent Calcul, R. Chow, +5 authors P. Crews
- Chemistry, Medicine
- Journal of natural products
- 13 February 2009
The overexpression of the Mcl-1 protein in cancerous cells results in the sequestering of Bak, a key component in the regulation of normal cell apoptosis. Our investigation of the ability of… Expand
Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.
- D. Bizub, A. Wood, A. M. Skalka
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 August 1986
The importance of mutational activation of the Ha-ras protooncogene in polycyclic aromatic hydrocarbon-induced mouse skin tumors was investigated in a complete carcinogenesis model using repetitive… Expand
Tumorigenicity of bay-region diol-epoxides and other benzo-ring derivatives of dibenzo(a,h)pyrene and dibenzo(a,i)pyrene on mouse skin and in newborn mice.
Abstract Dibenzo( a,h )pyrene, [DB( a,h )P], dibenzo( a,i )pyrene [DB( a,i )P], and seven of their benzo-ring derivatives were tested for tumorigenic activity on mouse skin and in newborn mice. In… Expand
Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids.
- M. Buening, R. Chang, M. Huang, J. Fortner, A. Wood, A. Conney
- Medicine
- Cancer research
- 1981
The effects of several naturally occurring and synthetic flavonoids on the metabolism of benzo(a)pyrene and aflatoxin B1 were evaluated. Addition of apigenin, chrysin, fisetin, flavonone, galangin,… Expand
Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.
- A. Wood, W. Levin, +4 authors A. Conney
- Chemistry, Medicine
- The Journal of biological chemistry
- 25 August 1976
A highly purified and reconstituted hepatic microsomal monooxygenase system, completely free of epoxide hydrase and consisting of cytochrome P-448 from 3-methylcholanthrene-treated rats,… Expand
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