Bcl-2-Like Protein 11, human

Known as: BCL2L11, Bcl-2 Interacting Protein Bim, BIML 
Bcl-2-like protein 11 (198 aa, ~22 kDa) is encoded by the human BCL2L11 gene. This protein is involved in the induction of apoptosis.
National Institutes of Health

Related topics

Related topics

11 relations
ApoptosisApoptosis PromoterBCL2L11 geneBCL2L11 wt Allele
(More)

Broader (1)

BCL2-Related Protein 11

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1.
The Bcl-2 antagonist ABT-737 kills transformed cells in association with displacement of Bim from Bcl-2. The histone deactetylase… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim
Endoplasmic reticulum (ER) stress caused by misfolded proteins or cytotoxic drugs can kill cells and although activation of this… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.
The proapoptotic protein Bim is expressed de novo following withdrawal of serum survival factors. Here, we show that Bim… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.
Both the ERK and phosphatidylinositol 3'-kinase (PI3K) signaling pathways can protect cells from apoptosis following withdrawal… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
During lymphocyte development, the assembly of genes coding for antigen receptors occurs by the combinatorial linking of gene… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis
Sympathetic neuronal death induced by nerve growth factor (NGF) deprivation requires the macromolecular synthesis-dependent… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim.
Apoptosis is triggered when proapoptotic members of the Bcl-2 protein family bearing only the BH3 association domain bind to Bcl… (More)
Is this relevant?
Review
2000
Review
2000
Tissue-specific Bcl-2 protein partners in apoptosis: An ovarian paradigm.
Apoptosis is an essential physiological process by which multicellular organisms eliminate superfluous cells. An expanding family… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1995
Highly Cited
1995
A new air displacement method for the determination of human body composition.
A new device based on the plethysmographic measurement of body volume has been developed for the purpose of estimating human body… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Evaluation of a new air displacement plethysmograph for measuring human body composition.
A new air displacement plethysmograph, the BOD POD (BP), was evaluated in comparison to hydrostatic weighing (HW). Sixty-eight… (More)
Is this relevant?