BW-755C

Inhibitors of arachidonic acid (AA) metabolism and other pharmacologic agents were evaluated against ear edema produced in mice… Expand

Muscle wasting is a critical feature of patients afflicted by AIDS or cancer. In a murine model of muscle wasting, tumor necrosis… Expand

Metabolites of arachidonic acid regulate several physiological processes, including vascular tone. The purpose of this study was… Expand

1. Inhibition of nitric oxide generation with Nw-nitro-L-arginine (nitroarginine) reduced vasodilator responses to bradykinin and… Expand

Concentrated ethanol causes gastric lesions by a mechanism that is poorly understood. We have investigated this mechanism in the… Expand

The stimulation of the human neutrophil NADPH-oxidase is initiated by a variety of agonists, which appear to utilize more than… Expand

To examine whether leukotrienes could increase blood-brain barrier permeability, rats were anesthetized and injected… Expand

Human leukocytes and platelets were preincubated with inhibitors of the oxidative metabolism of arachidonic acid, viz… Expand

The human colon synthetises several prostanoids which may have a role in inflammatory bowel diseases. As lipoxygenase products of… Expand

Leukocytic pyrogen (LP) is a polypeptide product of activated mononuclear phagocytes that has been established as the endogenous… Expand