BW-755C

Muscle wasting is a critical feature of patients afflicted by AIDS or cancer. In a murine model of muscle wasting, tumor necrosis… Expand

Concentrated ethanol causes gastric lesions by a mechanism that is poorly understood. We have investigated this mechanism in the… Expand

The stimulation of the human neutrophil NADPH-oxidase is initiated by a variety of agonists, which appear to utilize more than… Expand

The invasion of leukocytes into and around a myocardial infarct was studied in chloralose-anesthetized dogs subjected to 1-hr… Expand

Human leukocytes and platelets were preincubated with inhibitors of the oxidative metabolism of arachidonic acid, viz… Expand

BW755C (3‐amino‐1‐[m‐trifluoromethyl)phenyl]‐2‐pyrazoline HCl) reduced the concentration of leukotriene B4 (LTB4), thromboxane B2… Expand

The human colon synthetises several prostanoids which may have a role in inflammatory bowel diseases. As lipoxygenase products of… Expand

Leukocytic pyrogen (LP) is a polypeptide product of activated mononuclear phagocytes that has been established as the endogenous… Expand

Some non-steroid anti-inflammatory drugs which inhibit arachidonate cyclo-oxygenease have been examined for their effects on… Expand

Abstract All aspirin-like drugs so far tested inhibit prostaglandin biosynthesis but do not prevent the generation of the hydroxy… Expand