BW-755C

Pulmonary edema following smoke inhalation is due to the chemical toxins in smoke and not to the heat. We have shown that… (More)

Inhalation of smoke containing acrolein, the most common toxin in urban fires after carbon monoxide, causes vascular injury with… (More)

Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1) is present in cells under physiological… (More)

Metabolites of arachidonic acid regulate several physiological processes, including vascular tone. The purpose of this study was… (More)

1. The effects of bradykinin (BK) in the microcirculation of the isolated perfused heart of the rat were examined. The kinin… (More)

Concentrated ethanol causes gastric lesions by a mechanism that is poorly understood. We have investigated this mechanism in the… (More)

Inhibitors of arachidonic acid (AA) metabolism and other pharmacologic agents were evaluated against ear edema produced in mice… (More)

To examine whether leukotrienes could increase blood-brain barrier permeability, rats were anesthetized and injected… (More)

The invasion of leukocytes into and around a myocardial infarct was studied in chloralose-anesthetized dogs subjected to 1-hr… (More)

Human leukocytes and platelets were preincubated with inhibitors of the oxidative metabolism of arachidonic acid, viz… (More)