Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in α‐adrenoceptor responsiveness with age and disease in isolated tissues

@article{Christ1990PharmacologicalSO,
  title={Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in $\alpha$‐adrenoceptor responsiveness with age and disease in isolated tissues},
  author={George Joseph Christ and Saul Maayani and Mira Valcic and Arnold Melman},
  journal={British Journal of Pharmacology},
  year={1990},
  volume={101}
}
1 The pathophysiology of impotence related to vascular smooth muscle dysfunction in the male corpus cavernosum was studied on human isolated erectile tissue (HET). Studies were conducted on 140 sections of HET obtained from 38 male patients undergoing surgery for implantation of penile prostheses to correct underlying erectile dysfunction. 2 Spontaneous myotonic oscillations were characteristic of greater than 90% of all HET preparations at 37°C. These spontaneous oscillations were markedly… 
Characterization of nitroglycerine-induced relaxation in human corpus cavernosum smooth muscle: implications to erectile physiology and dysfunction.
TLDR
Statistical analysis revealed significant heterogeneity among corporal tissue strips derived from patients with organic erectile dysfunction, with respect to both the kinetic and steady-state characteristics of the NTG-induced relaxation and desensitization responses, which suggest that alterations in corporal smooth muscle responsivity to activation of the guanylate cyclase--cGMP pathway, per se, may be a characteristic of organic erectiles dysfunction.
Age-dependent alterations in the efficacy of phenylephrine-induced contractions in vascular smooth muscle isolated from the corpus cavernosum of impotent men.
TLDR
An increased efficacy of phenylephrine-induced contractions in vitro is consistent with the hypothesis that augmented corporal vascular smooth muscle contractility in vivo may contribute to the pathophysiology of impotence in older patients.
Functional response of cavernosal tissue to distension
TLDR
The hypothesis that, in cavernosal tissue, mechanotransduction of distension to contractile responses is an important determinant of detumescence is discussed, and a causal relation between Cavernosal tissue distension and phasic and tonic contractions is found.
On the putative mechanistic basis for intraoperative propofol-induced penile erections
TLDR
Data indicate that the mechanistic basis for intraoperative penile erections observed with propofol may be related, at least in part, to altered transmembrane calcium flux through voltage-dependent calcium channels, and thus, decreased corporal smooth muscle tone.
Comparative studies on rabbit corpus cavernosal contraction and relaxation. An in vitro study.
TLDR
The results demonstrate that virtually all of the inhibitory effects of field-stimulated relaxation could be explained by the release of nitric oxide, and suggest that L-NAME is a potent inhibitor of NO synthesis and can in a dose-dependent fashion inhibit over 95%.
Contractility changes of the deep dorsal penile vein due to serotonin.
TLDR
The present findings suggest that5-HT receptor functions in the DDPVs are of 5-HT2 subtype in potent men and the altered response to 5- HT in patients with veno-occlusive disease may play a role in the pathophysiology of impotence.
Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum.
TLDR
It is demonstrated that the cavernosal vasculature in CASTRATE animals possesses increased reactivity to alpha-adrenergic stimulation as compared to the sensitivity in TESTO rats, which concludes that one of the mechanisms by which androgens maintain erectile function is by regulating the alpha 1- adrenergic responsiveness of the cavernosa smooth muscle.
Alpha-adrenergic receptor blockade by phentolamine increases the efficacy of vasodilators in penile corpus cavernosum
TLDR
It is suggested that antagonism of α-adrenergic signaling enables other independent relaxatory pathways to predominate within penile trabecular smooth muscle.
Endothelium-dependency of yohimbine-induced corpus cavernosum relaxation
TLDR
The data indicate that the relaxant effect of yohimbine is both endothelium and androgen-dependent, which might justify the lack of efficacy of this drug in treatment of some form of organic erectile dysfunction.
...
...

References

SHOWING 1-10 OF 38 REFERENCES
Synthetic nitrovasodilators are effective, in vitro, in relaxing penile tissue from impotent men: the findings and their implications.
  • J. Heaton
  • Medicine, Biology
    Canadian journal of physiology and pharmacology
  • 1989
TLDR
The finding of a relaxant response to synthetic nitrovasodilators in "impotent" tissue implies that complete end organ failure is not always seen and endothelium-derived factors probably play a role in erectile tissue parallel with their role in other vascular tissues.
Potassium‐Induced Endothelium‐Dependent Rhythmic Activity in the Canine Basilar Artery
TLDR
It is suggested that increasing the concentration of extracellular potassium causes rhythmic activity in canine basilar arteries because of the production and/or release by the endothelium of products of cyclooxygenase such as prostaglandin F2α and E2.
Phentolamine‐induced rhythmic contractions in bladder detrusor muscle of guinea‐pig
TLDR
The results suggest that the phentolamine‐induced rhythmic contraction may, at least in part, result from the cyclo‐oxygenase metabolite of arachidonic acid in guinea‐pig detrusor muscles and a consequent increase in the transmembrane Ca2+‐influx.
Influence of diabetes on the reactivity of mesenteric microvessels to histamine, bradykinin and acetylcholine
TLDR
It is suggested that histamine and Bk antagonized the vasoconstrictor response of microvessels to NA through an action on lining endothelial cells resulting in increased vascular permeability and hyperosmolarity of extracellular fluids.
Coronary microvascular abnormalities in the hypertensive-diabetic rat. A primary cause of cardiomyopathy?
TLDR
It is proposed that the additive effects of hypertension and diabetes mellitus on the myocardial microcirculation may be a primary cause of cardiomyopathy in this model of human disease.
Adrenoreceptors in the human penis.
TLDR
Findings indicate that the motor response to sympathomimetic amines is the result of activation of alpha-adrenoreceptors in the corpus cavernosum muscle, which is likely to be either of the beta 1 or beta 2 type.
Pathophysiological Relevance of Serotonin
TLDR
The possibility that serotonergic mechanisms contribute to Raynaud's phenomenon and other vasospastic disorders is the subject of present discussions, although firm evidence for this view is not widely available.
Pathophysiological relevance of serotonin.
TLDR
The possibility that serotonergic mechanisms contribute to Raynaud's phenomenon and other vasospastic disorders is the subject of present discussions, although firm evidence for this view is not widely available.
...
...