Share This Author
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
- J. Mitchell, P. Akarasereenont, C. Thiemermann, R. Flower, J. Vane
- BiologyProceedings of the National Academy of Sciences…
- 15 December 1993
BF 389, an experimental drug currently being tested in humans, was the most potent and most selective inhibitor of COX-2 in intact cells, indicating there are clear pharmacological differences between the two enzymes.
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
This work identifies RvD2 as a potent endogenous regulator of excessive inflammatory responses that acts via multiple cellular targets to stimulate resolution and preserve immune vigilance in mice with microbial sepsis induced by caecal ligation and puncture and surgery.
Aberrant inflammation and resistance to glucocorticoids in Annexin 1−/− Mouse
It is reported that mice lacking the Anx‐1 gene exhibit a complex phenotype that includes an altered expression of other annexins as well as of COX‐2 and cPLA2 in response to carrageenin‐ or zymosan‐induced inflammation.
The electronic aggregometer: a novel device for assessing platelet behavior in blood.
Drugs which inhibit prostaglandin biosynthesis.
- R. Flower
- Biology, ChemistryPharmacological Reviews
- 1 March 1974
The participation of prostag landins in complex biological events may be investigated with the aid of substrate analogues or with pharmacological agents which block prostaglandin biosynthesis both in vitro and in vivo.
Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10.
- M. Ajuebor, A. Das, L. Virág, R. Flower, C. Szabó, M. Perretti
- Biology, MedicineJournal of Immunology
- 1 February 1999
A stimulus-dependent role of resident MCs inChemokine production and the existence of a regulatory loop between endogenous IL-10 and the chemokine-mediated cellular component of acute inflammation are proposed.
Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement.
Findings demonstrate for the first time distinct mechanisms of action for ANXA1 and its N-terminal peptide Ac2-26, which inhibited firm adhesion of human PMNs and significantly attenuated capture and rolling without effect on firmAdhesion.
Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)
Prostaglandin biosynthesis by aspirin-like drugs has now been confirmed in several systems and one of the few anomalies was that paracetamol, which has no anti-inflammatory activity, but is analgesic and anti-pyretic12, was inactive against dog spleen synthetase.
The development of COX2 inhibitors
- R. Flower
- BiologyNature reviews. Drug discovery
- 1 March 2003
The story of this discovery of a second form of the cyclooxygenase that was differentially sensitive to other aspirin-like drugs ultimately ushered in an exciting era of drug discovery, culminating in the introduction of an entirely new generation of anti-inflammatories.
Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor‐dependent, transcription‐independent mechanism
The results point to an unsuspected rapid effect of glucocorticoids, mediated by occupation of GR but not by changes in gene transcription, which is brought about by competition between LC1 and Grb2 leading to a failure of recruitment off signalling factors to EGF‐R.