• Publications
  • Influence
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
  • J. Vane
  • Chemistry, Medicine
  • Nature: New biology
  • 23 June 1971
Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
  • 7,898
  • 143
Cyclooxygenases 1 and 2.
Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several laboratories identified a productExpand
  • 2,633
  • 122
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.
The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with inhibition ofExpand
  • 1,400
  • 107
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, andExpand
  • 1,502
  • 60
  • PDF
The mechanism of action of aspirin.
The therapy of rheumatism began thousands of years ago with the use of decoctions or extracts of herbs or plants such as willow bark or leaves, most of which turned out to contain salicylates.Expand
  • 773
  • 30
  • PDF
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that inhibited human platelet aggregation. PGX was 30 times more potent in thisExpand
  • 2,960
  • 28
Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.
Cyclooxygenase (COX) converts arachidonic acid to prostaglandin H2, which is further metabolized to prostanoids. Two isoforms of COX exist: a constitutive (COX-1) and an inducible (COX-2) enzyme.Expand
  • 1,005
  • 27
Towards a better aspirin
  • J. Vane
  • Chemistry, Medicine
  • Nature
  • 20 January 1994
  • 682
  • 25