J. Vane

Publications658
h-index129
Citations81,932
Highly Influential Citations1,432
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
  • J. Vane
  • Chemistry, Medicine
  • Nature: New biology
  • 23 June 1971
Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
Cyclooxygenases 1 and 2.
TLDR
The discovery ofCOX-2 has made possible the design of drugs that reduce inflammation without removing the protective PGs in the stomach and kidney made by COX-1, which may not only be anti-inflammatory but may also be active in colon cancer and Alzheimer's disease. Expand
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.
TLDR
This full in vitro analysis of COx-1/2 selectivities in human tissues clearly supports the theory that inhibition of COX-1 underlies the gastrointestinal toxicity of NSAIDs in man. Expand
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
TLDR
BF 389, an experimental drug currently being tested in humans, was the most potent and most selective inhibitor of COX-2 in intact cells, indicating there are clear pharmacological differences between the two enzymes. Expand
Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies
The mechanism of action of aspirin.
TLDR
In 1971, Vane proved that aspirin and other non-steroid anti-inflammatory drugs (NSAIDs) inhibit the activity of the enzyme now called cyclooxygenase (COX) which leads to the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever. Expand
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
TLDR
A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions. Expand
Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.
TLDR
The rise in COX and NOS activities in the skin during the acute phase reinforces the proinflammatory role for prostanoids and suggests one also for nitric oxide and there may be differential regulation of these enzymes, perhaps due to the changing pattern of cytokines during the inflammatory response. Expand
Towards a better aspirin
  • J. Vane
  • Chemistry, Medicine
  • Nature
  • 20 January 1994
Regulatory functions of the vascular endothelium.
TLDR
The vascular endothelium, which envelops the circulating blood in a continuous monolayer, is mainly responsible for this function, but over the past 20 years numerous other important functions have been discovered. Expand
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