Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
- J. Vane
- Biology, MedicineNature: New biology
- 23 June 1971
Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
Cyclooxygenases 1 and 2.
- J. Vane, Y. S. Bakhle, R. Botting
- BiologyAnnual Review of Pharmacology and Toxicology
- 1998
The discovery ofCOX-2 has made possible the design of drugs that reduce inflammation without removing the protective PGs in the stomach and kidney made by COX-1, which may not only be anti-inflammatory but may also be active in colon cancer and Alzheimer's disease.
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.
- T. Warner, F. Giuliano, I. Vojnović, A. Bukasa, J. Mitchell, J. Vane
- Biology, MedicineProceedings of the National Academy of Sciences…
- 22 June 1999
This full in vitro analysis of COx-1/2 selectivities in human tissues clearly supports the theory that inhibition of COX-1 underlies the gastrointestinal toxicity of NSAIDs in man.
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
- J. Mitchell, P. Akarasereenont, C. Thiemermann, R. Flower, J. Vane
- BiologyProceedings of the National Academy of Sciences…
- 15 December 1993
BF 389, an experimental drug currently being tested in humans, was the most potent and most selective inhibitor of COX-2 in intact cells, indicating there are clear pharmacological differences between the two enzymes.
Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies
- S. Moncada, R. Gryglewski, M. J. Broekman
- Physics
- 2002
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
- S. Moncada, R. Gryglewski, S. Bunting, J. Vane
- Biology, MedicineNature
- 1 October 1976
A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions.
The mechanism of action of aspirin.
- J. Vane, R. Botting
- BiologyThrombosis Research
- 15 June 2003
Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.
- J. Vane, J. Mitchell, D. Willoughby
- Biology, MedicineProceedings of the National Academy of Sciences…
- 15 March 1994
The rise in COX and NOS activities in the skin during the acute phase reinforces the proinflammatory role for prostanoids and suggests one also for nitric oxide and there may be differential regulation of these enzymes, perhaps due to the changing pattern of cytokines during the inflammatory response.
Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.
- G. De Nucci, R. Thomas, J. Vane
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 December 1988
In the rat, the effects of endothelin on the blood pressure vary from pressor (in pithed rats) to purely depressor in anesthetized rats where the resting blood pressure is high, and has the characteristics of a local pressor hormone, rather than a circulating one.
Regulatory functions of the vascular endothelium.
- J. Vane, E. Anggard, R. Botting
- Biology, MedicineNew England Journal of Medicine
- 5 July 1990
The vascular endothelium, which envelops the circulating blood in a continuous monolayer, is mainly responsible for this function, but over the past 20 years numerous other important functions have been discovered.
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