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Antisense Oligonucleotides

Known as: Antisense Agents, Oligonucleotides, Anti-Sense, AS ODNs 
Small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the ability of the RNA to make a protein or work in other ways… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Here, we discuss three RNA-based therapeutic technologies exploiting various oligonucleotides that bind to RNA by base pairing in… Expand
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Review
2010
Review
2010
Dramatic advances in understanding of the roles RNA plays in normal health and disease have greatly expanded over the past 10… Expand
Highly Cited
2006
Highly Cited
2006
Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a… Expand
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Highly Cited
2006
Highly Cited
2006
MicroRNAs (miRNAs) are a class of 20–24 nt noncoding RNAs that regulate target mRNAs post-transcriptionally by binding with… Expand
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Review
2003
Review
2003
  • J. Kurreck
  • European journal of biochemistry
  • 2003
  • Corpus ID: 25723633
Antisense agents are valuable tools to inhibit the expression of a target gene in a sequence-specific manner, and may be used for… Expand
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Highly Cited
2002
Highly Cited
2002
The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied… Expand
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Highly Cited
2000
Highly Cited
2000
Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a… Expand
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Highly Cited
2000
Highly Cited
2000
Survivin, an inhibitor of apoptosis protein, deserves attention as a selective target for cancer therapy because it lacks… Expand
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Highly Cited
1993
Highly Cited
1993
We have used a previously described 17-mer phosphorothioate (Monia, B.P., Johnston, J.F., Ecker, D. J., Zounes, M.A., Lima, W.F… Expand
Highly Cited
1990
Highly Cited
1990
NEURONS in culture can have fundamentally distinct morphologies which permit their cytological identification and the recognition… Expand