Antisense Oligonucleotides

Known as: Antisense Agents, Oligonucleotides, Anti-Sense, AS ODNs 
Small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the ability of the RNA to make a protein or work in other ways… (More)

Topic mentions per year

Topic mentions per year

1951-2018
020040019512017

Papers overview

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Review
2016
Review
2016
RNA therapeutics refers to the use of oligonucleotides to target primarily ribonucleic acids (RNA) for therapeutic efforts or in… (More)
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Review
2015
Review
2015
Spinal muscular atrophy (SMA) is a major neurodegenerative disorder of children and infants. SMA is primarily caused by low… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Duchenne's muscular dystrophy is associated with severe, progressive muscle weakness and typically leads to death… (More)
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Highly Cited
2006
Highly Cited
2006
MicroRNAs (miRNAs) are a class of 20-24 nt noncoding RNAs that regulate target mRNAs post-transcriptionally by binding with… (More)
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Highly Cited
2006
Highly Cited
2006
Neurotoxicity from accumulation of misfolded/mutant proteins is thought to drive pathogenesis in neurodegenerative diseases… (More)
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Highly Cited
2002
Highly Cited
2002
The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied… (More)
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Highly Cited
2002
Highly Cited
2002
Efficiencies of a nuclease resistant antisense oligonucleotide and of siRNA both being targeted against the green fluorescent… (More)
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Highly Cited
2000
Highly Cited
2000
Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a… (More)
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Highly Cited
1993
Highly Cited
1993
Each neuron in the mammalian brain carries many postsynaptic membrane specializations containing high densities of receptors that… (More)
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Highly Cited
1990
Highly Cited
1990
Neurons in culture can have fundamentally distinct morphologies which permit their cytological identification and the recognition… (More)
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