FAQ

Antisense Oligonucleotides

Known as: Antisense Agents, Oligonucleotides, Anti-Sense, AS ODNs 
Small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the ability of the RNA to make a protein or work in other ways… (More)

Topic mentions per year

Topic mentions per year

1951-2018
020040019512017

Related topics

Related topics

23 relations

Broader (2)

Antisense Elements (Genetics)Oligonucleotides
Antisense Oligonucleotide [EPC]In BloodMorpholinosProcess of secretion
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Narrower (7)

GEM91ISIS 1082ISIS 3466ISIS 5132
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Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Antisense Oligonucleotides
agonists
Oligonucleotides
chemical synthesis
Morpholinos
standards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
RNA therapeutics: RNAi and antisense mechanisms and clinical applications.
  • Jessica Chery
  • Postdoc journal : a journal of postdoctoral…
  • 2016
RNA therapeutics refers to the use of oligonucleotides to target primarily ribonucleic acids (RNA) for therapeutic efforts or in… (More)
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Review
2015
Review
2015
Mechanistic principles of antisense targets for the treatment of spinal muscular atrophy.
Spinal muscular atrophy (SMA) is a major neurodegenerative disorder of children and infants. SMA is primarily caused by low… (More)
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Highly Cited
2007
Highly Cited
2007
Local dystrophin restoration with antisense oligonucleotide PRO051.
BACKGROUND Duchenne's muscular dystrophy is associated with severe, progressive muscle weakness and typically leads to death… (More)
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Highly Cited
2006
Highly Cited
2006
Improved targeting of miRNA with antisense oligonucleotides
MicroRNAs (miRNAs) are a class of 20-24 nt noncoding RNAs that regulate target mRNAs post-transcriptionally by binding with… (More)
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Highly Cited
2006
Highly Cited
2006
Antisense oligonucleotide therapy for neurodegenerative disease.
Neurotoxicity from accumulation of misfolded/mutant proteins is thought to drive pathogenesis in neurodegenerative diseases… (More)
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Highly Cited
2002
Highly Cited
2002
Design of antisense oligonucleotides stabilized by locked nucleic acids.
The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied… (More)
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Highly Cited
2002
Highly Cited
2002
Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.
Efficiencies of a nuclease resistant antisense oligonucleotide and of siRNA both being targeted against the green fluorescent… (More)
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Highly Cited
2000
Highly Cited
2000
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.
Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a… (More)
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Highly Cited
1993
Highly Cited
1993
Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons.
Each neuron in the mammalian brain carries many postsynaptic membrane specializations containing high densities of receptors that… (More)
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Highly Cited
1990
Highly Cited
1990
Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons.
Neurons in culture can have fundamentally distinct morphologies which permit their cytological identification and the recognition… (More)
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