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Antisense Oligonucleotides

Known as: Antisense Agents, Oligonucleotides, Anti-Sense, AS ODNs 
Small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the ability of the RNA to make a protein or work in other ways… Expand
National Institutes of Health

Related topics

Related topics

22 relations

Broader (2)

Antisense Elements (Genetics)Oligonucleotides
Antisense Oligonucleotide [EPC]In BloodMorpholinosProcess of secretion
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Narrower (8)

GEM91ISIS 1082ISIS 3466ISIS 5132
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
FDA-Approved Oligonucleotide Therapies in 2017.
Oligonucleotides (oligos) have been under clinical development for approximately the past 30 years, beginning with antisense… Expand
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Review
2017
Review
2017
Preventing cardiovascular heart disease: Promising nutraceutical and non-nutraceutical treatments for cholesterol management.
Hypercholesterolemia is one of the major risk factors for the development of cardiovascular disease. Atherosclerosis resulting… Expand
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Review
2012
Review
2012
RNA therapeutics: beyond RNA interference and antisense oligonucleotides
Here, we discuss three RNA-based therapeutic technologies exploiting various oligonucleotides that bind to RNA by base pairing in… Expand
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Highly Cited
2007
Highly Cited
2007
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
MicroRNAs are predicted to regulate thousands of mammalian genes, but relatively few targets have been experimentally validated… Expand
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Highly Cited
2006
Highly Cited
2006
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.
Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a… Expand
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Highly Cited
2006
Highly Cited
2006
Antisense oligonucleotide therapy for neurodegenerative disease.
Neurotoxicity from accumulation of misfolded/mutant proteins is thought to drive pathogenesis in neurodegenerative diseases… Expand
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Highly Cited
2006
Highly Cited
2006
Improved targeting of miRNA with antisense oligonucleotides
MicroRNAs (miRNAs) are a class of 20–24 nt noncoding RNAs that regulate target mRNAs post-transcriptionally by binding with… Expand
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Review
2003
Review
2003
Antisense technologies. Improvement through novel chemical modifications.
  • Jens Kurreck
  • European journal of biochemistry
  • 2003
    • Corpus ID: 25723633
Antisense agents are valuable tools to inhibit the expression of a target gene in a sequence-specific manner, and may be used for… Expand
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Highly Cited
2000
Highly Cited
2000
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.
Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a… Expand
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Highly Cited
1990
Highly Cited
1990
Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons
NEURONS in culture can have fundamentally distinct morphologies which permit their cytological identification and the recognition… Expand
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