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Antisense Oligonucleotides

Known as: Antisense Agents, Oligonucleotides, Anti-Sense, AS ODNs 
Small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the ability of the RNA to make a protein or work in other ways… 
National Institutes of Health

Related topics

Related topics

22 relations

Broader (2)

Antisense Elements (Genetics)Oligonucleotides
Antisense Oligonucleotide [EPC]In BloodMorpholinosProcess of secretion

Narrower (8)

GEM91ISIS 1082ISIS 3466ISIS 5132

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Is there a future for cell-penetrating peptides in oligonucleotide delivery?
Highly Cited
2006
Highly Cited
2006
Xapelin and Xmsr are required for cardiovascular development in Xenopus laevis.
Highly Cited
2002
Highly Cited
2002
A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.
PURPOSE Protein kinase C (PKC)-alpha and Raf-1 are important elements of proliferative signal transduction pathways in both… 
Highly Cited
2000
Highly Cited
2000
Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide.
Cancers overexpressing Bcl-2 protein, which prevents programmed cell death (apoptosis), are less sensitive to stresses that… 
Highly Cited
1999
Highly Cited
1999
GABAA, D1, and D5, but not progestin receptor, antagonist and anti-sense oligonucleotide infusions to the ventral tegmental area of cycling rats and hamsters attenuate lordosis
Highly Cited
1999
Highly Cited
1999
Growth inhibition of human pancreatic cancer cell lines by anti‐sense oligonucleotides specific to mutated K‐ras genes
About 90% of human pancreatic cancers carry K‐ras point mutation, which may play an important role in tumorigenesis. We… 
Highly Cited
1998
Highly Cited
1998
A new non-viral DNA delivery vector: the terplex system.
Review
1997
Review
1997
Antisense oligonucleotides as therapeutics for malignant diseases.
The continued progress in our understanding of the biology of neoplasia and in the identification, cloning, and sequencing of… 
Highly Cited
1993
Highly Cited
1993
Introduction of antisense oligonucleotides into cells by permeabilization with streptolysin O.
Cellular uptake of antisense oligonucleotides is critical to their ability to inhibit gene expression. In the present study… 
Highly Cited
1992
Highly Cited
1992
Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices
Antisense oligonucleotides (ASOs) are designed to bind to a specific mRNA and selectively suppress its translation. To facilitate… 
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