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Antisense Oligonucleotides

Known as: Antisense Agents, Oligonucleotides, Anti-Sense, AS ODNs 
Small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the ability of the RNA to make a protein or work in other ways… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Oligonucleotides (oligos) have been under clinical development for approximately the past 30 years, beginning with antisense… Expand
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Review
2017
Review
2017
Hypercholesterolemia is one of the major risk factors for the development of cardiovascular disease. Atherosclerosis resulting… Expand
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Review
2012
Review
2012
Here, we discuss three RNA-based therapeutic technologies exploiting various oligonucleotides that bind to RNA by base pairing in… Expand
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Highly Cited
2007
Highly Cited
2007
MicroRNAs are predicted to regulate thousands of mammalian genes, but relatively few targets have been experimentally validated… Expand
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Highly Cited
2006
Highly Cited
2006
Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a… Expand
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Highly Cited
2006
Highly Cited
2006
Neurotoxicity from accumulation of misfolded/mutant proteins is thought to drive pathogenesis in neurodegenerative diseases… Expand
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Highly Cited
2006
Highly Cited
2006
MicroRNAs (miRNAs) are a class of 20–24 nt noncoding RNAs that regulate target mRNAs post-transcriptionally by binding with… Expand
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Review
2003
Review
2003
  • Jens Kurreck
  • European journal of biochemistry
  • 2003
  • Corpus ID: 25723633
Antisense agents are valuable tools to inhibit the expression of a target gene in a sequence-specific manner, and may be used for… Expand
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Highly Cited
2000
Highly Cited
2000
Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a… Expand
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Highly Cited
1990
Highly Cited
1990
NEURONS in culture can have fundamentally distinct morphologies which permit their cytological identification and the recognition… Expand
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