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Antisense Oligonucleotides

Known as: Antisense Agents, Oligonucleotides, Anti-Sense, AS ODNs 
Small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the ability of the RNA to make a protein or work in other ways… Expand
National Institutes of Health

Related topics

Related topics

22 relations

Broader (2)

Antisense Elements (Genetics)Oligonucleotides
Antisense Oligonucleotide [EPC]In BloodMorpholinosProcess of secretion
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Narrower (8)

GEM91ISIS 1082ISIS 3466ISIS 5132
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
RNA therapeutics: beyond RNA interference and antisense oligonucleotides
Here, we discuss three RNA-based therapeutic technologies exploiting various oligonucleotides that bind to RNA by base pairing in… Expand
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Review
2010
Review
2010
RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform.
Dramatic advances in understanding of the roles RNA plays in normal health and disease have greatly expanded over the past 10… Expand
Highly Cited
2006
Highly Cited
2006
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.
Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a… Expand
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Highly Cited
2006
Highly Cited
2006
Improved targeting of miRNA with antisense oligonucleotides
MicroRNAs (miRNAs) are a class of 20–24 nt noncoding RNAs that regulate target mRNAs post-transcriptionally by binding with… Expand
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Review
2003
Review
2003
Antisense technologies. Improvement through novel chemical modifications.
  • J. Kurreck
  • European journal of biochemistry
  • 2003
    • Corpus ID: 25723633
Antisense agents are valuable tools to inhibit the expression of a target gene in a sequence-specific manner, and may be used for… Expand
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Highly Cited
2002
Highly Cited
2002
Design of antisense oligonucleotides stabilized by locked nucleic acids.
The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied… Expand
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Highly Cited
2000
Highly Cited
2000
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.
Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a… Expand
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Highly Cited
2000
Highly Cited
2000
A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy.
Survivin, an inhibitor of apoptosis protein, deserves attention as a selective target for cancer therapy because it lacks… Expand
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Highly Cited
1993
Highly Cited
1993
Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.
We have used a previously described 17-mer phosphorothioate (Monia, B.P., Johnston, J.F., Ecker, D. J., Zounes, M.A., Lima, W.F… Expand
Highly Cited
1990
Highly Cited
1990
Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons
NEURONS in culture can have fundamentally distinct morphologies which permit their cytological identification and the recognition… Expand
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