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Novel injectable neutral solutions of chitosan form biodegradable gels in situ.
This study reports for the first time the use of polymer/polyol salt aqueous solutions as gelling systems, suggesting the discovery of a prototype for a new family of thermosetting gels highly compatible with biological compounds. Expand
Block copolymer micelles: preparation, characterization and application in drug delivery.
The innovations in block copolymer synthesis, polymeric micelle preparation and characterization, as well as the relevance of these developments to the field of biomedical research are proposed. Expand
Polymeric micelles - a new generation of colloidal drug carriers.
  • M. Jones, J. Leroux
  • Chemistry, Medicine
  • European journal of pharmaceutics and…
  • 1 September 1999
This review examines the chemical nature of polymeric micelles as well as the methods used to characterize them with regard to drug delivery and potential medical applications, especially in cancer chemotherapy, are described and discussed. Expand
Characterization of thermosensitive chitosan gels for the sustained delivery of drugs.
Results indicate that the chitosan/GP thermosensitive solutions gel rapidly at body temperature, can remain in the sol state at 4 degrees C and can sustain the delivery of macromolecules. Expand
pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates.
This review describes the current status of pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates and their performance as nano-scale drug delivery systems, with emphasis on the recent contribution to this field. Expand
Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules.
Results indicate that the liposome-C-GP system rapidly gels at body temperature, and can sustain the delivery of low-molecular-weight hydrophilic compounds. Expand
Stereocomplex block copolymer micelles: core-shell nanostructures with enhanced stability.
This study demonstrates the advantages of stereocomplex formation in the design of stabilized water-soluble nanoparticles with kinetic stability and redispersion properties superior to micelles prepared with isotactic or racemic polymers alone. Expand
Toxicity of silver nanoparticles in macrophages.
Detailed characterization of the particles by X-ray diffraction and electron microscopy reveals that the size of the nanosilver is well controlled, and direct silver nanoparticle-macrophage interactions dominate the Nanosilver toxicity at sizes larger than 10 nm. Expand
Investigational new treatments for Clostridium difficile infection.
A snapshot of the current stage of these breakthroughs is provided and it is argued that there is still room for further innovation in treating C. difficile infection. Expand
Biodegradable nanoparticles — From sustained release formulations to improved site specific drug delivery
Abstract Biodegradable poly( dl -lactic acid) nanoparticles (NP) produced by the salting-out process were evaluated in vitro and in vivo for their sustained release properties and their capacity toExpand