Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

ISIS 5132

Known as: ISIS 5132/CGP69846A, ISIS-5132, ISIS5132 
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
A novel gene transfection vector was fabricated based on the conjugation of human serum albumin (HSA) and maleimide end… Expand
Is this relevant?
2009
2009
BACKGROUND A phase I trial was performed to evaluate the administration of carboplatin/paclitaxel in combination with ISIS-5132… Expand
Is this relevant?
2003
2003
OBJECTIVE ISIS 5132 is a 20-base phosphorothioate DNA oligonucleotide against human c-raf kinase, a downstream effector of ras… Expand
Is this relevant?
Highly Cited
2002
Highly Cited
2002
PURPOSE Protein kinase C (PKC)-alpha and Raf-1 are important elements of proliferative signal transduction pathways in both… Expand
Is this relevant?
2002
2002
BACKGROUND Because treatment of metastatic colon cancer is noncurative, new treatments are needed. This trial evaluated the… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Raf-1 is a serine/threonine kinase that functions as a critical effector of Ras-mediated signal transduction via the mitogen… Expand
  • table 1
  • table 2
  • table 3
  • figure 1
  • table 4
Is this relevant?
2001
2001
Two multicentre phase II trials were designed to determine if tumour responses can be achieved in progressive small-cell lung… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Raf proteins play a central role in the mitogen-activated protein kinase signaling pathway and hence are involved in oncogenic… Expand
  • table 1
  • table 2
  • table 3
  • table 4
  • figure 1
Is this relevant?
1999
1999
PURPOSE Raf-1 is a protein kinase that plays a broad role in oncogenic signaling and acts as a downstream effector of Ras in the… Expand
Is this relevant?
1999
1999
Abnormally regulated signaling through proliferative signal transduction pathways characterizes many of the common solid tumors… Expand
  • figure 1
  • table 1
  • figure 2
Is this relevant?