ISIS 5132

Known as: ISIS 5132/CGP69846A, ISIS-5132, ISIS5132 
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2014
024619962014

Papers overview

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2009
2009
BACKGROUND A phase I trial was performed to evaluate the administration of carboplatin/paclitaxel in combination with ISIS-5132… (More)
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2006
2006
In vitro ultrafiltration was used to determine the plasma protein-binding characteristics of phosphorothioate oligonucleotides… (More)
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2003
2003
OBJECTIVE ISIS 5132 is a 20-base phosphorothioate DNA oligonucleotide against human c-raf kinase, a downstream effector of ras… (More)
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2002
2002
PURPOSE Protein kinase C (PKC)-alpha and Raf-1 are important elements of proliferative signal transduction pathways in both… (More)
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2002
2002
BACKGROUND Because treatment of metastatic colon cancer is noncurative, new treatments are needed. This trial evaluated the… (More)
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2001
2001
Raf-1 is a serine/threonine kinase that functions as a critical effector of Ras-mediated signal transduction via the mitogen… (More)
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2001
2001
Two multicentre phase II trials were designed to determine if tumour responses can be achieved in progressive small-cell lung… (More)
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2000
2000
Raf proteins play a central role in the mitogen-activated protein kinase signaling pathway and hence are involved in oncogenic… (More)
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1999
1999
PURPOSE Raf-1 is a protein kinase that plays a broad role in oncogenic signaling and acts as a downstream effector of Ras in the… (More)
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1999
1999
Abnormally regulated signaling through proliferative signal transduction pathways characterizes many of the common solid tumors… (More)
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