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ISIS 5132
Known as:
ISIS 5132/CGP69846A
, ISIS-5132
, ISIS5132
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress…
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National Institutes of Health
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Related topics
Related topics
5 relations
Broader (4)
Antineoplastic Agents
Antisense Oligonucleotides
Enzyme Inhibitors
Thionucleotides
Narrower (1)
CGP 69846A
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Phase II Randomized Study of ISIS 3521 and ISIS 5132 in Patients with Locally Advanced or Metastatic Colorectal Cancer : A National Cancer Institute of Canada Clinical Trials Group Study 1
M. Cripps
,
A. Figueredo
,
+6 authors
E. Eisenhauer
2002
Corpus ID: 5173786
Background: Because treatment of metastatic colon cancer is noncurative, new treatments are needed. This trial evaluated the…
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2002
2002
A Randomized Phase II and Pharmacokinetic Study of the Antisense Oligonucleotides ISIS 3521 and ISIS 5132 in Patients with Hormone-refractory Prostate Cancer 1
A. Tolcher
,
L. Reyno
,
+8 authors
E. Eisenhauer
2002
Corpus ID: 14914420
Purpose: Protein kinase C (PKC)and Raf-1 are important elements of proliferative signal transduction pathways in both normal and…
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