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ISIS 5132

Known as: ISIS 5132/CGP69846A, ISIS-5132, ISIS5132 
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress… 
National Institutes of Health

Papers overview

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2018
2018
Gene therapy through systemic administration is expected to offer significant therapeutic potential against intractable cancers… 
2015
2015
A novel gene transfection vector was fabricated based on the conjugation of human serum albumin (HSA) and maleimide end… 
2009
2009
Background: A phase I trial was performed to evaluate the administration of carboplatin/paclitaxel in combination with ISIS-5132… 
Highly Cited
2002
Highly Cited
2002
PURPOSE Protein kinase C (PKC)-alpha and Raf-1 are important elements of proliferative signal transduction pathways in both… 
Highly Cited
2002
Highly Cited
2002
BACKGROUND Because treatment of metastatic colon cancer is noncurative, new treatments are needed. This trial evaluated the… 
Highly Cited
2001
Highly Cited
2001
Raf-1 is a serine/threonine kinase that functions as a critical effector of Ras-mediated signal transduction via the mitogen… 
Highly Cited
2000
Highly Cited
2000
Raf proteins play a central role in the mitogen-activated protein kinase signaling pathway and hence are involved in oncogenic… 
Highly Cited
1999
Highly Cited
1999
PURPOSE Raf-1 is a protein kinase that plays a broad role in oncogenic signaling and acts as a downstream effector of Ras in the… 
Highly Cited
1999
Highly Cited
1999
Abnormally regulated signaling through proliferative signal transduction pathways characterizes many of the common solid tumors… 
1998
1998
Small, single‐stranded, chemically modified oligonucleotides, complementary to a specific gene section, commonly referred to as…