Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

ISIS 5132

Known as: ISIS 5132/CGP69846A, ISIS-5132, ISIS5132 
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Background: A phase I trial was performed to evaluate the administration of carboplatin/paclitaxel in combination with ISIS-5132… Expand
Highly Cited
2003
Highly Cited
2003
OBJECTIVE ISIS 5132 is a 20-base phosphorothioate DNA oligonucleotide against human c-raf kinase, a downstream effector of ras… Expand
Highly Cited
2002
Highly Cited
2002
PURPOSE Protein kinase C (PKC)-alpha and Raf-1 are important elements of proliferative signal transduction pathways in both… Expand
Highly Cited
2002
Highly Cited
2002
BACKGROUND Because treatment of metastatic colon cancer is noncurative, new treatments are needed. This trial evaluated the… Expand
Highly Cited
2001
Highly Cited
2001
Raf-1 is a serine/threonine kinase that functions as a critical effector of Ras-mediated signal transduction via the mitogen… Expand
  • table 1
  • table 2
  • table 3
  • figure 1
  • table 4
Highly Cited
2001
Highly Cited
2001
Two multicentre phase II trials were designed to determine if tumour responses can be achieved in progressive small-cell lung… Expand
Highly Cited
2000
Highly Cited
2000
Raf proteins play a central role in the mitogen-activated protein kinase signaling pathway and hence are involved in oncogenic… Expand
  • table 1
  • table 2
  • table 3
  • table 4
  • figure 1
Highly Cited
1999
Highly Cited
1999
PURPOSE Raf-1 is a protein kinase that plays a broad role in oncogenic signaling and acts as a downstream effector of Ras in the… Expand
Highly Cited
1999
Highly Cited
1999
Abnormally regulated signaling through proliferative signal transduction pathways characterizes many of the common solid tumors… Expand
  • figure 1
  • table 1
  • figure 2
1998
1998
Small, single‐stranded, chemically modified oligonucleotides, complementary to a specific gene section, commonly referred to as… Expand