Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 205,752,044 papers from all fields of science
Search
Sign In
Create Free Account
ISIS 5132
Known as:
ISIS 5132/CGP69846A
, ISIS-5132
, ISIS5132
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
5 relations
Broader (4)
Antineoplastic Agents
Antisense Oligonucleotides
Enzyme Inhibitors
Thionucleotides
Narrower (1)
CGP 69846A
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Safety of nanoparticles based on albumin-polymer conjugates as a carrier of nucleotides for pancreatic cancer therapy.
K. Taguchi
,
Hongxu Lu
,
Yanyan Jiang
,
Tzong-tyng Hung
,
M. Stenzel
Journal of materials chemistry. B
2018
Corpus ID: 105105491
Gene therapy through systemic administration is expected to offer significant therapeutic potential against intractable cancers…
Expand
2015
2015
An Oligonucleotide Transfection Vector Based on HSA and PDMAEMA Conjugation: Effect of Polymer Molecular Weight on Cell Proliferation and on Multicellular Tumor Spheroids.
Yanyan Jiang
,
Chin Ken Wong
,
M. Stenzel
Macromolecular bioscience
2015
Corpus ID: 36010945
A novel gene transfection vector was fabricated based on the conjugation of human serum albumin (HSA) and maleimide end…
Expand
2009
2009
Phase I Study of the c-raf-1 Antisense Oligonucleotide ISIS 5132 in Combination with Carboplatin and Paclitaxel in Patients with Previously Untreated, Advanced Non-small Cell Lung Cancer
P. Fidias
,
N. Pennell
,
+8 authors
J. Supko
Journal of thoracic oncology : official…
2009
Corpus ID: 3141045
Background: A phase I trial was performed to evaluate the administration of carboplatin/paclitaxel in combination with ISIS-5132…
Expand
Highly Cited
2002
Highly Cited
2002
A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.
A. Tolcher
,
L. Reyno
,
+8 authors
E. Eisenhauer
Clinical cancer research : an official journal of…
2002
Corpus ID: 7830995
PURPOSE Protein kinase C (PKC)-alpha and Raf-1 are important elements of proliferative signal transduction pathways in both…
Expand
Highly Cited
2002
Highly Cited
2002
Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada clinical trials group study.
M. Cripps
,
A. Figueredo
,
+6 authors
E. Eisenhauer
Clinical cancer research : an official journal of…
2002
Corpus ID: 21820710
BACKGROUND Because treatment of metastatic colon cancer is noncurative, new treatments are needed. This trial evaluated the…
Expand
Highly Cited
2001
Highly Cited
2001
Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.
C. Rudin
,
J. Holmlund
,
+10 authors
M. Ratain
Clinical cancer research : an official journal of…
2001
Corpus ID: 28117447
Raf-1 is a serine/threonine kinase that functions as a critical effector of Ras-mediated signal transduction via the mitogen…
Expand
Highly Cited
2000
Highly Cited
2000
A phase I trial of c-Raf kinase antisense oligonucleotide ISIS 5132 administered as a continuous intravenous infusion in patients with advanced cancer.
C. C. Cunningham
,
J. Holmlund
,
+4 authors
J. Nemunaitis
Clinical cancer research : an official journal of…
2000
Corpus ID: 30352156
Raf proteins play a central role in the mitogen-activated protein kinase signaling pathway and hence are involved in oncogenic…
Expand
Highly Cited
1999
Highly Cited
1999
Phase I clinical/pharmacokinetic and pharmacodynamic trial of the c-raf-1 antisense oligonucleotide ISIS 5132 (CGP 69846A).
J. Stevenson
,
K. Yao
,
+9 authors
P. O'dwyer
Journal of clinical oncology : official journal…
1999
Corpus ID: 28812535
PURPOSE Raf-1 is a protein kinase that plays a broad role in oncogenic signaling and acts as a downstream effector of Ras in the…
Expand
Highly Cited
1999
Highly Cited
1999
c-raf-1 depletion and tumor responses in patients treated with the c-raf-1 antisense oligodeoxynucleotide ISIS 5132 (CGP 69846A).
P. O'dwyer
,
J. Stevenson
,
+6 authors
K. Yao
Clinical cancer research : an official journal of…
1999
Corpus ID: 14503011
Abnormally regulated signaling through proliferative signal transduction pathways characterizes many of the common solid tumors…
Expand
1998
1998
Preconcentration and separation of antisense oligonucleotides by on‐column isotachophoresis and capillary electrophoresis in polymer‐filled capillaries
I. Barmé
,
G. Bruin
,
A. Paulus
,
M. Ehrat
Electrophoresis
1998
Corpus ID: 29364009
Small, single‐stranded, chemically modified oligonucleotides, complementary to a specific gene section, commonly referred to as…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
,
Terms of Service
, and
Dataset License
ACCEPT & CONTINUE