Morpholinos

Known as: MORF Oligomers, Phosphorodiamidate Morpholino Oligomers, Morpholino 
An antisense oligonucleotide modified to be more stable than RNA. While morpholinos have standard nucleic acid bases, those bases are bound to… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
The widespread availability of programmable site-specific nucleases now enables targeted gene disruption in the zebrafish. In… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND We report clinical safety and biochemical efficacy from a dose-ranging study of intravenously administered AVI-4658… (More)
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Highly Cited
2010
Highly Cited
2010
Exon-skipping efficacies of phosphodiamidate morpholino oligomers (PMOs) or the conjugates of PMOs with cell-penetrating peptides… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Mutations that disrupt the open reading frame and prevent full translation of DMD, the gene that encodes dystrophin… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE Duchenne muscular dystrophy (DMD) is caused by the inability to produce dystrophin protein at the myofiber membrane. A… (More)
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Highly Cited
2008
Highly Cited
2008
We have developed a new transporter structure that provides effective delivery of Morpholino antisense oligomers into a wide… (More)
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Highly Cited
2007
Highly Cited
2007
Several vertebrate microRNAs (miRNAs) have been implicated in cellular processes such as muscle differentiation, synapse function… (More)
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Highly Cited
2003
Highly Cited
2003
This paper describes the compatibility of poly(dimethylsiloxane) (PDMS) with organic solvents; this compatibility is important in… (More)
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Highly Cited
2000
Highly Cited
2000
The sequencing of the zebrafish genome should be completed by the end of 2002. Direct assignment of function on the basis of this… (More)
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Review
1999
Review
1999
RNase H-competent phosphorothioates (S-DNAs) have dominated the antisense field in large part because they offer reasonable… (More)
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