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Ansamycins

Known as: Ansamycin Antibiotics, Ansamycin Antineoplastic Antibiotic, ansamycin 
An antineoplastic antibiotic of macrocyclic benzoquinone isolated from the bacterial genus Streptomyces. Ansamycin antibiotics bind to and inhibit… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Lactams, Macrocyclic

Narrower (2)

MycobutinRifabutin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
From ergot to ansamycins-45 years in biosynthesis.
In this review the author traces his scientific career from its beginnings in Germany to his moves to, successively, Purdue… 
Highly Cited
2000
Highly Cited
2000
Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.
The ansamycin antibiotics, herbimycin A (HA) and geldanamycin (GM), bind to a conserved pocket in heat shock protein 90 (Hsp90… 
Highly Cited
1999
Highly Cited
1999
Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases.
Benzoquinoid ansamycins, such as herbimycin A (HA) and geldanamycin (GA), are antibiotics that exhibit anti-tumor effects. These… 
Review
1997
Review
1997
Enantioselectivity in capillary electrophoresis using the macrocyclic antibiotics.
1996
1996
Cell protein cross-linking by erbstatin and related compounds.
Highly Cited
1994
Highly Cited
1994
Use of a macrocyclic antibiotic, rifamycin B, and indirect detection for the resolution of racemic amino alcohols by CE.
Ansamycins are a very specific class of macrocyclic antibiotics of which the rifamycins are among the better known members… 
Highly Cited
1993
Highly Cited
1993
Asymmetric synthesis of the benzoquinoid ansamycin antitumor antibiotics : total synthesis of (+)-macbecin
A convergent asymmetric synthesis of the antitumor antibiotic macbecin I has been achieved. Six of the seven stereogenic centers… 
Highly Cited
1982
Highly Cited
1982
Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II.
The structures of mycotrienins I and II have been determined mainly by their NMR spectral analysis. Mycotrienins are unique… 
Highly Cited
1982
Highly Cited
1982
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II.
Mycotrienins I and II have been isolated from the cultured broth of Streptomyces rishiriensis. Taxonomical studies of the… 
1980
1980
Ansamitocins, maytansinoid antitumor antibiotics. Producing organism, fermentation, and antimicrobial activities.
The general pharmacology of aclacinomycin A, a new antitumor antibiotic, was studied in mice, rats, guinea-pigs, frogs, rabbits… 
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