Ansamycins

Known as: Ansamycin Antibiotics, Ansamycin Antineoplastic Antibiotic, ansamycin 
An antineoplastic antibiotic of macrocyclic benzoquinone isolated from the bacterial genus Streptomyces. Ansamycin antibiotics bind to and inhibit… (More)
National Institutes of Health

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Highly Cited
2002
Highly Cited
2002
Ansamycin antibiotics, such as 17-allylaminogeldanamycin (17-AAG), bind to Hsp90 and regulate its function, resulting in the… (More)
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Highly Cited
2002
Highly Cited
2002
Breast cancers with high expression of HER2 are associated frequently with aggressive, poor prognosis disease and resistance to… (More)
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Highly Cited
2001
Highly Cited
2001
17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) is an ansamycin antibiotic that binds to a conserved pocket in Hsp90 and… (More)
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Highly Cited
2000
Highly Cited
2000
The ansamycin antibiotics, herbimycin A (HA) and geldanamycin (GM), bind to a conserved pocket in heat shock protein 90 (Hsp90… (More)
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Highly Cited
1996
Highly Cited
1996
Treatment of SKBr3 cells with benzoquinone ansamycins, such as geldanamycin (GA), depletes p185erbB2, the receptor tyrosine… (More)
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Highly Cited
1996
Highly Cited
1996
The role of the abundant stress protein Hsp90 in protecting cells against stress-induced damage is not well understood. The… (More)
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Highly Cited
1995
Highly Cited
1995
The plasma pharmacokinetics of the antitumor antibiotic geldanamycin (GM; NSC 122750), a naturally occurring benzoquinoid… (More)
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Highly Cited
1994
Highly Cited
1994
The molecular mechanisms by which oncogenic tyrosine kinases induce cellular transformation are unclear. Herbimycin A… (More)
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Highly Cited
1992
Highly Cited
1992
The benzoquinonoid ansamycin antibiotics herbimycin A and geldanamycin have been shown to reverse the oncogenic phenotype of… (More)
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Highly Cited
1986
Highly Cited
1986
Three benzenoid ansamycin antibiotics (herbimycin, macbecin, and geldanamycin) were found to reduce the intracellular… (More)
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