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Ansamycins

Known as: Ansamycin Antibiotics, Ansamycin Antineoplastic Antibiotic, ansamycin 
An antineoplastic antibiotic of macrocyclic benzoquinone isolated from the bacterial genus Streptomyces. Ansamycin antibiotics bind to and inhibit… Expand
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
ABSTRACT Geldanamycin and the closely related herbimycins A, B, and C were the first benzoquinone ansamycins to be extensively… Expand
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Highly Cited
2002
Highly Cited
2002
Ansamycin antibiotics, such as 17-allylaminogeldanamycin (17-AAG), bind to Hsp90 and regulate its function, resulting in the… Expand
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Highly Cited
2002
Highly Cited
2002
PURPOSE Ansamycin antibiotics, including 17allylamino-17-demethoxygeldanamycin (17-AAG), inhibit Hsp90 function and cause the… Expand
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Highly Cited
2001
Highly Cited
2001
17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) is an ansamycin antibiotic that binds to a conserved pocket in Hsp90 and… Expand
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Review
1998
Review
1998
Successful expression of polypeptide gene products requires transcription machinery to generate messenger ribonucleic acids and… Expand
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Highly Cited
1996
Highly Cited
1996
The role of the abundant stress protein Hsp90 in protecting cells against stress-induced damage is not well understood. The… Expand
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Highly Cited
1996
Highly Cited
1996
Treatment of SKBr3 human breast carcinoma cells with the benzoquinoid ansamycin, geldanamycin, rapidly depletes p185c-erbB-2… Expand
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Highly Cited
1996
Highly Cited
1996
Treatment of SKBr3 cells with benzoquinone ansamycins, such as geldanamycin (GA), depletes p185erbB2, the receptor tyrosine… Expand
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Highly Cited
1995
Highly Cited
1995
The plasma pharmacokinetics of the antitumor antibiotic geldanamycin (GM; NSC 122750), a naturally occurring benzoquinoid… Expand
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Highly Cited
1994
Highly Cited
1994
The molecular mechanisms by which oncogenic tyrosine kinases induce cellular transformation are unclear. Herbimycin A… Expand
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