T. Sasaki

Publications58
h-index21
Citations1,004
Highly Influential Citations19
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TPU-0031-A and B, new antibiotics of the novobiocin group produced by Streptomyces sp. TP-A0556.
Two novel antibiotics, TPU-0031-A and B, were isolated from the culture broth of an actinomycete strain. The producing strain, TP-A0556, was identified as Streptomyces sp. based on the taxonomic… Expand
TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598.
In screening for anti-MRSA antibiotics, novel lydicamycin congeners, TPU-0037-A, B, C and D, were isolated from a culture broth of an actinomycete strain. The producing strain, TP-A0598, was isolated… Expand
A new tetracycline antibiotic with antitumor activity. I. Taxonomy and fermentation of the producing strain, isolation and characterization of SF2575.
A new antitumor antibiotic SF2575 has been isolated from a culture filtrate of Streptomyces sp. SF2575. The molecular formula was determined to be C40H43NO15 by elemental analysis, mass and 13C NMR… Expand
Studies on the biosynthesis of bialaphos (SF-1293). 2. Isolation of the first natural products with a C-P-H bond and their involvement in the C-P-C bond formation.
2-Phosphinomethylmalic acid (PMM) synthase catalyzes the condensation of phosphinopyruvic acid (PPA), an analog of oxalacetic acid, and acetyl-CoA to form PMM. The enzyme was purified approximately… Expand
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II.
Mycotrienins I and II have been isolated from the cultured broth of Streptomyces rishiriensis. Taxonomical studies of the producing organism, fermentation, isolation and characterization of the… Expand
Diazaphilonic acid, a new azaphilone with telomerase inhibitory activity.
Throughour screening programofbioactive secondary metabolites of microbial origin, we have isolated a new azaphilone-type metabolite, diazaphilonic acid (Fig. 1). In this paper, we report the… Expand
3D culture of murine hematopoietic cells with spatial development of stromal cells in nonwoven fabrics.
BACKGROUND The in vivo hematopoietic microenvironment is composed of stromal cells and extracellular matrix in a 3D configuration. We have created a 3D microenvironment in vitro, employing spatial… Expand
Isolation of Actinomycetes from Live Plants and Evaluation of Antiphytopathogenic Activity of Their Metabolites
Actinomycetes were isolated from live plants collected in Toyama and Miyagi prefectures, Japan. Three hundred and ninety eight actinomycete strains were obtained from the leaves, stems and roots of… Expand
Cedarmycins A and B, new antimicrobial antibiotics from Streptomyces sp. TP-A0456.
Two novel butyrolactone antibiotics, cedarmycins A and B, were isolated from the cultured broth of the actinomycete Streptomyces sp. TP-A0456. The new compounds were purified by HP-20 resin, silica… Expand
CONFORMATIONAL ANALYSIS OF C3'-C8 CONNECTED BIFLAVONES
Two biflavones isolated from Taxus cuspidata were identified with ginkgetin (1) and sciadopitysin (2) which belong to C3′-C8 connected biflavones. The conformation of 2 in the solid state was… Expand
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