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Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.
The data implicate O2- in the hypertension of SHR in vivo and suggest that the antihypertensive action of tempol depends on NO synthesis presumably because O 2- inactivates NO and thus diminishes its vasodilatory actions. Expand
Morphological study of the mammalian stress response: characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat
Using both electron microscopy and immunological methods, a number of changes occurring in rat fibroblasts after heat-shock treatment are characterized, including changes in both the number and size of the granular ribonucleoprotein components and a reorganization of the nucleolar fibrillar reticulum. Expand
Role of the major heat shock proteins as molecular chaperones.
Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression.
Angiotensin (ANG) II infusion stimulates oxidative stress via AT1-R, which increases the renal cortical mRNA expression of p22phox and Nox-1 and reduces abundance of Nx-4 and EC-SOD, and is offset by strong protective effects of AT2-R. Expand
Nephron pO2 and renal oxygen usage in the hypertensive rat kidney.
A precapillary O2 shunt reduces the pO2 of cortical nephrons in SHRs because of less efficient O2 usage for Na+ transport. Expand
Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation
A signaling pathway from ROCK1 to profilin thus controls polyglutamine protein aggregation and is targeted by a promising therapeutic lead for HD. Expand
Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly.
A model consistent with these data suggests that under normal growth conditions, cytosolic Hsp 72,73 interact transiently with nascent polypeptides to facilitate proper folding, and that metabolic stress interferes with these events. Expand
Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein.
Treatment of delta F508 CFTR-expressing cells with any one of these compounds, which are referred to as 'chemical chaperones', restored the ability of the mutant cells to exhibit forskolin-dependent chloride transport, similar to that observed for the cells expressing the wild-type CFTR protein. Expand
Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding.
Circular dichroism and HPLC gel filtration were used to show that cytosolic hsp70 is thermally stable but undergoes a conformational transition leading to oligomerization, which is significant only at physiologically relevant temperatures. Expand