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Rifabutin

Known as: Ansamycin, Rifamycin XIV, 1',4-didehydro-1-deoxy-1,4-dihydro-5'-(2-methylpropyl)-1-oxo-, 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin xiv 
A semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby… 
National Institutes of Health

Related topics

Related topics

33 relations

Narrower (8)

AlfacidEC5 compoundLM-427Mycobutin

Broader (4)

AnsamycinsAnti-Bacterial AgentsAntibiotics, AntitubercularAntitubercular Agents
Antimycobacterial agentDecreased Protein Synthesis [PE]Drug AllergyIn Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
BIIB021, an oral, synthetic non-ansamycin Hsp90 inhibitor: Phase I experience
2503 Background: BIIB021 is an oral fully synthetic Hsp90 inhibitor that is being developed for both solid and hematologic tumors… 
Review
2004
Review
2004
Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation-induced injury
ABSTRACTInducible heat shock protein 70 kD (HSP-70i) has been shown to protect cells, tissues, and organs from harmful assaults… 
Highly Cited
2003
Highly Cited
2003
Randomized controlled study of rabeprazole, levofloxacin and rifabutin triple therapy vs. quadruple therapy as second‐line treatment for Helicobacter pylori infection
Aim : To test the efficacy of rabeprazole, levofloxacin and rifabutin triple therapy vs. quadruple therapy for the second‐line… 
Highly Cited
2003
Highly Cited
2003
Geldanamycin inhibits the production of inflammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcripts.
OBJECTIVE Heat-shock protein 90 (Hsp90) is critical in the intracellular signaling pathways that promote inflammatory cytokine… 
Highly Cited
2002
Highly Cited
2002
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the…
Anaplastic large cell lymphomas (ALCL) are characterized by the expression of a chimeric protein, NPM-ALK, which originates from… 
Highly Cited
2000
Highly Cited
2000
Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.
The ansamycin antibiotics, herbimycin A (HA) and geldanamycin (GM), bind to a conserved pocket in heat shock protein 90 (Hsp90… 
Highly Cited
2000
Highly Cited
2000
The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation
Abstract The 90-kDa heat shock protein (Hsp90) is the most abundant molecular chaperone of eukaryotic cells. Its chaperone… 
Highly Cited
1999
Highly Cited
1999
Geldanamycin Provides Posttreatment Protection Against Glutamate‐Induced Oxidative Toxicity in a Mouse Hippocampal Cell Line
Abstract : The benzoquinoid ansamycin geldanamycin interferes with many cell signaling pathways and is currently being evaluated… 
Highly Cited
1994
Highly Cited
1994
Use of a macrocyclic antibiotic, rifamycin B, and indirect detection for the resolution of racemic amino alcohols by CE.
Ansamycins are a very specific class of macrocyclic antibiotics of which the rifamycins are among the better known members… 
Highly Cited
1987
Highly Cited
1987
Studies on the biosynthesis of the alpha-glucosidase inhibitor acarbose: valienamine, a m-C7N unit not derived from the shikimate pathway.
Feeding experiments with Actinoplanes sp. SN223/29 showed that 3-amino-5-hydroxy-[7-13C]benzoic acid is not incorporated into… 
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