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Rifabutin

Known as: Ansamycin, Rifamycin XIV, 1',4-didehydro-1-deoxy-1,4-dihydro-5'-(2-methylpropyl)-1-oxo-, 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin xiv 
A semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Increasing resistance to antibiotics worldwide has adverse effects on the effectiveness of standard therapies to eradicate… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND & AIMS Mycobacterium avium subspecies paratuberculosis has been proposed as a cause of Crohn's disease. We report a… Expand
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Highly Cited
2001
Highly Cited
2001
Huntington's disease (HD) is a progressive neurodegenerative disorder with no effective treatment. Geldanamycin is a benzoquinone… Expand
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Highly Cited
2000
Highly Cited
2000
Oxidative stress can trigger neuronal cell death and has been implicated in several chronic neurological diseases and in acute… Expand
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Highly Cited
1998
Highly Cited
1998
Purpose: Benzoquinone ansamycins are antibiotics with anticancer potential. First described as tyrosine kinase inhibitors, they… Expand
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Highly Cited
1997
Highly Cited
1997
In response to the need for rapid, inexpensive, high-throughput assays for antimycobacterial drug screening, a microplate-based… Expand
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Highly Cited
1996
Highly Cited
1996
Treatment of SKBr3 human breast carcinoma cells with the benzoquinoid ansamycin, geldanamycin, rapidly depletes p185c-erbB-2… Expand
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Highly Cited
1995
Highly Cited
1995
Cytosolic Raf-1 exists in a high molecular weight complex with the heat shock protein Hsp90, the purpose of which is unknown. The… Expand
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Highly Cited
1994
Highly Cited
1994
The molecular mechanisms by which oncogenic tyrosine kinases induce cellular transformation are unclear. Herbimycin A… Expand
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Highly Cited
1990
Highly Cited
1990
Diagnostic Criteria of Nontuberculous Mycobacterial Lung Disease For patients with a cavitary infiltrate: Two or more sputums or… Expand
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