Rifabutin

Known as: Ansamycin, Rifamycin XIV, 1',4-didehydro-1-deoxy-1,4-dihydro-5'-(2-methylpropyl)-1-oxo-, 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin xiv 
A semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2018
05019742018

Papers overview

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Highly Cited
2007
Highly Cited
2007
BACKGROUND & AIMS Mycobacterium avium subspecies paratuberculosis has been proposed as a cause of Crohn's disease. We report a… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND The occurrence of acquired rifamycin resistance despite use of directly observed therapy for tuberculosis is… (More)
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Highly Cited
2005
Highly Cited
2005
Somatic mutations in the kinase domain of the epidermal growth factor receptor (EGFR), including L858R and exon 19 deletions… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE Ansamycin antibiotics, including 17allylamino-17-demethoxygeldanamycin (17-AAG), inhibit Hsp90 function and cause the… (More)
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Highly Cited
2002
Highly Cited
2002
Ansamycin antibiotics, such as 17-allylaminogeldanamycin (17-AAG), bind to Hsp90 and regulate its function, resulting in the… (More)
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1999
1999
Eighty-one clinical isolates of Helicobacter pylori showed no resistance to rifampin (MIC range, 0.032 to 2 microg/ml; MIC at… (More)
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Highly Cited
1998
Highly Cited
1998
We compared the in-vitro antimycobacterial activities of rifabutin and KRM-1648, two rifamycin derivatives, with that of… (More)
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Highly Cited
1997
Highly Cited
1997
In response to the need for rapid, inexpensive, high-throughput assays for antimycobacterial drug screening, a microplate-based… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Azithromycin is active in treating Mycobacterium avium complex disease, but it has not been evaluated as primary… (More)
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1989
1989
We investigated the pharmacokinetics of rifabutin in 15 male patients as part of a phase I trial of the treatment of early… (More)
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