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Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray.
In summary, immunostains can be used to determine the GCB and non-GCB subtypes of DLBCL and predict survival similar to the cDNA microarray. Expand
A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group.
An international review of lymphomas found that each of us had independently evolved ways of viewing these diseases that were essentially identical, and there was little divergence between European and US participants. Expand
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
- B. Falini, C. Mecucci, +20 authors M. Martelli
- Biology, Medicine
- The New England journal of medicine
- 20 January 2005
Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype, NPM gene mutations, and responsiveness to induction chemotherapy. Expand
The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated…
Results obtained indicate that Ki-1 antigen is an inducible lymphoid-associated molecule that identifies a group of hitherto poorly characterized normal and neoplastic large lymphoid cells in Hodgkin's disease and Disorders in which only a minority of cells express Ki- 1 antigen probably represent lesions in whichonly some of the abnormal cells have transformed into an "activation state. Expand
A revised European-American classification of lymphoid neoplasms : a proposal from the international lymphoma study group
CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features.
Recent immunohistologic studies suggest that ALCLs Hodgkin-like represent either cases of tumor cell-rich classic Hodgkin disease or (less commonly) ALK(+) ALCL orALK(-) ALCL, both of which have an unfavorable prognosis. Expand
Nucleophosmin and cancer
The aim of this review is to analyse the role of NPM in cancer, and examine how deregulated NPM activity (either gain or loss of function) can contribute to tumorigenesis. Expand
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation.
It is shown for the first time in humans that adoptive transfer of Tregs prevented GVHD in the absence of any posttransplantation immunosuppression, promoted lymphoid reconstitution, improved immunity to opportunistic pathogens, and did not weaken the graft-versus-leukemia effect. Expand
Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases
Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases shows clear trends in prognosis and disease progression. Expand
A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells.
The results suggest that MUM1 is involved in the late stages of B-cell differentiation and in T-cell activation and is deregulated in DLCL-B. Expand