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Pharmacokinetically guided dose adjustment of 5-fluorouracil: a rational approach to improving therapeutic outcomes.
- M. Saif, A. Choma, S. J. Salamone, E. Chu
- Journal of the National Cancer Institute
- 18 November 2009
Chemotherapy dosing of the fluoropyrimidine 5-fluorouracil (5-FU) is currently based on body surface area. However, body surface area-based dosing has been associated with clinically significant… Expand
Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE Study.
- H. Hochster, L. Hart, +9 authors E. Hedrick
- Journal of clinical oncology : official journal…
- 20 July 2008
PURPOSE To evaluate the safety and efficacy of three oxaliplatin and fluoropyrimidine regimens, with or without bevacizumab, as first-line treatment for metastatic colorectal cancer (CRC). PATIENTS… Expand
Primary pancreatic lymphomas.
- M. Saif
- JOP : Journal of the pancreas
- 9 May 2006
Primary pancreatic lymphomas are extremely rare. Clinically, primary pancreatic lymphomas usually present with symptoms of carcinoma of the pancreatic head. Patients with primary pancreatic lymphomas… Expand
Hypersensitivity Reactions Associated with Platinum Antineoplastic Agents: A Systematic Review
- N. Makrilia, E. Syrigou, I. Kaklamanos, L. Manolopoulos, M. Saif
- Metal-based drugs
- 20 September 2010
Platinum-containing chemotherapy agents (cisplatin, carboplatin, oxaliplatin) have been approved in the first-line setting of numerous malignancies, such as ovarian, bladder, head and neck,… Expand
Gastrointestinal Perforation Due to Bevacizumab in Colorectal Cancer
Bevacizumab is the first U.S. Food and Drug Association-approved vascular endothelial growth factor-targeted agent that greatly increases progression-free and overall survival in combination with… Expand
Disparities in colorectal cancer in African-Americans vs Whites: before and after diagnosis.
There are differences between African-American and white patients with colorectal cancer, concerning their characteristics before and after diagnosis. Whites are more likely to adhere to screening… Expand
Diabetes and pancreatic cancer.
There is great emphasis on early identification of high risk patients for developing pancreatic cancer in an attempt to reduce the burden of the fourth leading cause of cancer death in the United… Expand
Management of oxaliplatin-induced peripheral neuropathy
Neurotoxicity is the most frequent dose-limiting toxicity of oxaliplatin. Acute sensory neurotoxicity manifests as rapid onset of cold-induced distal dysesthesia and/or paresthesia, sometimes… Expand
Fluoropyrimidine-associated cardiotoxicity: revisited.
BACKGROUND The syndrome of 5-fluorouracil (5-FU)-associated cardiotoxicity remains poorly defined. PATIENTS AND METHODS We performed a literature review (1969 - 2007) and compiled data derived from… Expand
Serum Alkaline Phosphatase Level as a Prognostic Tool in Colorectal Cancer: A Study of 105 patients.
BACKGROUND: Serum alkaline phosphotase (ALP) levels are frequently elevated in patients with metastatic colorectal cancer (CRC). However, the significance of ALP in terms of detecting hepatic… Expand