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Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis
Fosmidomycin inhibited 1-deoxy-d-xylulose 5-phosphate reductoisomerase pathway for terpenoid biosynthesis with IC50 of 8.2 nM.
An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190.
The results indicate that orfD encodes an unusual IPP isomerase showing no sequence similarity to those of IPp isomerases identified to date, considered to be a suitable molecular target for the screening of antibacterial drugs specific to S. aureus.
Diversity of the biosynthesis of the isoprene units.
This review covers the biosynthesis of the starter units of terpenoids via the nonmevalonate pathway together with a new enzyme involved in the conversion of IPP and DMAPP, i.e type 2 IPP isomerase.
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus.
Simultaneous operation of the mevalonate and non-mevalonate pathways in the biosynthesis of isopentenly diphosphate in Streptomyces aeriouvifer
Abstract Labeling experiments using [1,2-13C2]acetate and [U-13C6]glucose on menaquinone and naphterpin produced by Streptomyces aeriouvifer proved simultaneous operation of the mevalonate and
An Alternative Menaquinone Biosynthetic Pathway Operating in Microorganisms
The outline of this alternative pathway in a nonpathogenic strain of Streptomyces is deduced by bioinformatic screening, gene knockouts, shotgun cloning with isolated mutants, and in vitro studies with recombinant enzymes.
Cloning and Characterization of 1-Deoxy-d-Xylulose 5-Phosphate Synthase fromStreptomyces sp. Strain CL190, Which Uses both the Mevalonate and Nonmevalonate Pathways for Isopentenyl Diphosphate
The recombinant enzyme overexpressed in Escherichia coli was purified as a soluble protein and characterized, showing the same enzymatic properties of E. coli DXP synthases, although these two enzymes had different origins.
Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis
Transgenic plants expressing the antisense AtMECT gene, encoding 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, were generated to elucidate the physiological role of the nonmevalonate pathway for production of ent-kaurene, the latter being the plastidic precursor of gibberellins.
Structural basis for antibiotic recognition by the TipA class of multidrug‐resistance transcriptional regulators
The classical globin fold is well adapted not only for accommodating its canonical cofactors, heme and other tetrapyrroles, but also for the recognition of a variety of antibiotics where ligand binding leads to transcriptional activation and drug resistance.
Gizzerosine, a New Toxic Substance in Fish Meal, Causes Severe Gizzard Erosion in Chicks
A new substance, 2-amino-9-(4-imidazolyl)-7-azanonanoic acid, has been isolated from mackerel meal and named Gizzerosine, which caused severe gizzard erosion in chiks within a week when it was fed to them at the level of 2.2 ppm in the diet.