H. Seto

Publications272
h-index36
Citations5,168
Highly Influential Citations107
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Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis
Fosmidomycin inhibited 1-deoxy-d-xylulose 5-phosphate reductoisomerase pathway for terpenoid biosynthesis with IC50 of 8.2 nM.
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Diversity of the biosynthesis of the isoprene units.
This review covers the biosynthesis of the starter units of terpenoids, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) via the nonmevalonate pathway together with a new enzyme… Expand
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Simultaneous operation of the mevalonate and non-mevalonate pathways in the biosynthesis of isopentenly diphosphate in Streptomyces aeriouvifer
Abstract Labeling experiments using [1,2-13C2]acetate and [U-13C6]glucose on menaquinone and naphterpin produced by Streptomyces aeriouvifer proved simultaneous operation of the mevalonate and… Expand
  • 126
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An Alternative Menaquinone Biosynthetic Pathway Operating in Microorganisms
In microorganisms, menaquinone is an obligatory component of the electron-transfer pathway. It is derived from chorismate by seven enzymes in Escherichia coli. However, a bioinformatic analysis of… Expand
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Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis
Abstract. Transgenic plants of Arabidopsis thaliana (L.) Heynh. (ecotype Columbia) expressing the antisense AtMECT gene, encoding 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, were… Expand
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Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol from 2-C-methyl-d-erythritol 4-phosphate by 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate…
2-C-Methyl-d-erythritol 4-phosphate is transformed to 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol in the presence of cytidine 5′-triphosphate by a novel Escherichia coli enzyme,… Expand
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Structural basis for antibiotic recognition by the TipA class of multidrug‐resistance transcriptional regulators
The TipAL protein, a bacterial transcriptional regulator of the MerR family, is activated by numerous cyclic thiopeptide antibiotics. Its C‐terminal drug‐binding domain, TipAS, defines a subfamily of… Expand
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Direct formation of 2-C-methyl-d-erythritol 4-phosphate from 1-deoxy-d-xylulose 5-phosphate by 1-deoxy-d-xylulose 5-phosphate reductoisomerase, a new enzyme in the non-mevalonate pathway to…
Abstract 1-Deoxy- d -xylulose 5-phosphate is biotransformed to 2-C-methyl- d -erythritol 4-phosphate in a single step in the presence of NADPH by a new recombinant enzyme named 1-deoxy- d -xylulose… Expand
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Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol kinase
Abstract A nonmevalonate pathway intermediate, 4-(cytidine 5′-diphospho)-2- C -methyl- d -erythritol, is transformed to its 2-phospho-derivative in the presence of ATP by a novel Escherichia coli… Expand
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Bioactive Natural Products with Carbon—Phosphorus Bonds and Their Biosynthesis
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