Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis
- T. Kuzuyama, Tomohiro Shimizu, Shunji Takahashi, H. Seto
- Chemistry, Biology
- 22 October 1998
An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190.
- K. Kaneda, T. Kuzuyama, M. Takagi, Y. Hayakawa, H. Seto
- BiologyProceedings of the National Academy of Sciences…
- 30 January 2001
The results indicate that orfD encodes an unusual IPP isomerase showing no sequence similarity to those of IPp isomerases identified to date, considered to be a suitable molecular target for the screening of antibacterial drugs specific to S. aureus.
Diversity of the biosynthesis of the isoprene units.
- T. Kuzuyama, H. Seto
- ChemistryNatural product reports (Print)
- 25 March 2003
This review covers the biosynthesis of the starter units of terpenoids via the nonmevalonate pathway together with a new enzyme involved in the conversion of IPP and DMAPP, i.e type 2 IPP isomerase.
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus.
- K. Shin‐ya, K. Wierzba, H. Seto
- BiologyJournal of the American Chemical Society
- 20 January 2001
Cloning and Characterization of 1-Deoxy-d-Xylulose 5-Phosphate Synthase fromStreptomyces sp. Strain CL190, Which Uses both the Mevalonate and Nonmevalonate Pathways for Isopentenyl Diphosphate…
- T. Kuzuyama, M. Takagi, Shunji Takahashi, H. Seto
- BiologyJournal of Bacteriology
- 15 February 2000
The recombinant enzyme overexpressed in Escherichia coli was purified as a soluble protein and characterized, showing the same enzymatic properties of E. coli DXP synthases, although these two enzymes had different origins.
Structural basis for antibiotic recognition by the TipA class of multidrug‐resistance transcriptional regulators
- J. Kahmann, H. Sass, M. Allan, H. Seto, C. Thompson, S. Grzesiek
- Biology, ChemistryEMBO Journal
- 15 April 2003
The classical globin fold is well adapted not only for accommodating its canonical cofactors, heme and other tetrapyrroles, but also for the recognition of a variety of antibiotics where ligand binding leads to transcriptional activation and drug resistance.
Simultaneous operation of the mevalonate and non-mevalonate pathways in the biosynthesis of isopentenly diphosphate in Streptomyces aeriouvifer
- H. Seto, Hiroyuki Watanabe, K. Furihata
- Biology, Chemistry
- 28 October 1996
Protein purification and function assignment of the epoxidase catalyzing the formation of fosfomycin.
- P. Liu, K. Murakami, H. Liu
- BiologyJournal of the American Chemical Society
- 21 April 2001
Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis
- T. Kuzuyama, H. Seto
- Biology, ChemistryProceedings of the Japan Academy. Series B…
- 9 March 2012
This review article focuses on the significant contributions to a comprehensive understanding of the biosynthesis of IPP and DMAPP, the mevalonate-independent 2-C-methyl-d-erythritol 4-phosphate pathway.
...
...