Amiloride

Known as: 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide, Amiloride [Chemical/Ingredient], Amiloridum 
A synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2017
020040019672017

Papers overview

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Highly Cited
2010
Highly Cited
2010
Macropinocytosis is differentiated from other types of endocytosis by its unique susceptibility to inhibitors of Na(+)/H… (More)
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Highly Cited
2002
Highly Cited
2002
Many painful inflammatory and ischemic conditions such as rheumatoid arthritis, cardiac ischemia, and exhausted skeletal muscles… (More)
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Highly Cited
1997
Highly Cited
1997
Sodium balance, and ultimately blood pressure and extracellular fluid volume, is maintained by precise regulation of the activity… (More)
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Highly Cited
1994
Highly Cited
1994
THE amiloride-sensitive epithelial sodium channel constitutes the rate-limiting step for sodium reabsorption in epithelial cells… (More)
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Highly Cited
1993
Highly Cited
1993
A fibroblast mutant cell line devoid of Na+/H+ exchange was used to stably express cDNAs encoding the NHE1, NHE2, and NHE3 Na+/H… (More)
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Highly Cited
1991
Highly Cited
1991
An increase in cytosolic free calcium (Cai) has been shown to occur early during ischemia in perfused rat, ferret, and rabbit… (More)
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Highly Cited
1987
Highly Cited
1987
The diuretic drug amiloride, an inhibitor of Na+ uptake, competitively inhibits the catalytic activity of the urokinase-type… (More)
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Highly Cited
1984
Highly Cited
1984
An important early event in mammalian gustatory transduction with respect to sodium chloride has been found to be the passage of… (More)
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Highly Cited
1981
Highly Cited
1981
We examined the effect of amiloride on Na+-H+ exchange in rabbit renal cortical microvillus membrane vesicles. Amiloride… (More)
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Highly Cited
1968
Highly Cited
1968
1 Amiloride inhibits Na transport and short-circuit current (SCC) across the toad bladder. It is 1000 times more active at the… (More)
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