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Amiloride

Known as: 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide, Amiloride [Chemical/Ingredient], Amiloridum 
A synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Inhibitors of Na+/H+ exchange proteins block macropinocytosis by lowering the pH near the plasma membrane, which in turn inhibits… Expand
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Highly Cited
2002
Highly Cited
2002
Many painful inflammatory and ischemic conditions such as rheumatoid arthritis, cardiac ischemia, and exhausted skeletal muscles… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND The efficacy of new antihypertensive drugs has been questioned. We compared the effects of conventional and newer… Expand
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Highly Cited
1997
Highly Cited
1997
Sodium balance, and ultimately blood pressure and extracellular fluid volume, is maintained by precise regulation of the activity… Expand
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Highly Cited
1995
Highly Cited
1995
Cystic fibrosis transmembrane regulator (CFTR), the gene product that is mutated in cystic fibrosis (CF) patients, has a well… Expand
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Highly Cited
1995
Highly Cited
1995
THE peptide Phe-Met-Arg-Phe-NH2 (FMRFamide) and structurally related peptides are present both in invertebrate and vertebrate… Expand
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Highly Cited
1994
Highly Cited
1994
THE amiloride-sensitive epithelial sodium channel constitutes the rate-limiting step for sodium reabsorption in epithelial cells… Expand
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Highly Cited
1989
Highly Cited
1989
Measurement of pH in tissue has shown that the microenvironment in tumors is generally more acidic than in normal tissues. Major… Expand
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Highly Cited
1984
Highly Cited
1984
An important early event in mammalian gustatory transduction with respect to sodium chloride has been found to be the passage of… Expand
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Review
1982
Review
1982
  • Dale J. Benos
  • The American journal of physiology
  • 1982
  • Corpus ID: 21835995
The potassium-sparing diuretic amiloride has proven to be a useful pharmacological tool for elucidating the molecular basis and… Expand
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