Pyrazinamide

Known as: Pyrazineamide, Pyrazinamide [Chemical/Ingredient], Pirazinamida 
A synthetic pyrazinoic acid amide derivative with bactericidal property. Pyrazinamide is particularly active against slowly multiplying intracellular… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1951-2018
010020019512017

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND New drugs, but also shorter, better-tolerated regimens are needed to tackle the high global burden of tuberculosis… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND We explored the association between antituberculosis drug pharmacokinetics and treatment outcomes among patients with… (More)
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Highly Cited
2009
Highly Cited
2009
There are currently renewed efforts to develop drugs that could shorten the duration of antituberculosis therapy. This is best… (More)
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Highly Cited
2008
Highly Cited
2008
PA-824 is a nitroimidazo-oxazine in clinical testing for the treatment of tuberculosis. We report that the novel combination of… (More)
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Highly Cited
2006
Highly Cited
2006
Evaluation of sources of pharmacokinetic variation can facilitate optimization of tuberculosis treatment regimens by… (More)
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Highly Cited
2005
Highly Cited
2005
The incidence of tuberculosis has been increasing substantially on a worldwide basis over the past decade, but no tuberculosis… (More)
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Highly Cited
2003
Highly Cited
2003
Pyrazinamide is an important sterilizing drug that shortens tuberculosis (TB) therapy. However, the mechanism of action of… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Tuberculosis is a common complication of HIV-1 infection, especially in developing countries. Practical and effective… (More)
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Highly Cited
1997
Highly Cited
1997
Isoniazid (INH), rifampin (RIF), and pyrazinamide (PZA) are the most important drugs for the treatment of tuberculosis (TB). The… (More)
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Highly Cited
1996
Highly Cited
1996
The aim of this study was to determine the current incidence of side-effects severe enough to cause intolerance of standard… (More)
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