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5-hydroxypyrazinamide

National Institutes of Health

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Pyrazinamide
analogs & derivatives

Papers overview

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1995
1995
Xylitol-induced increase in the concentration of oxypurines and its mechanism.
We investigated the effect of xylitol on the plasma concentration and the urinary excretion of purine bases, 5… 
1994
1994
In vitro and in vivo study on the conversion of allopurinol and pyrazinamide.
Allopurinol is widely used in the treatment of gout. The main metabolic pathway of allopurinol is its oxidation to oxypurinol… 
1991
1991
A case of xanthinuria: a study on the metabolism of pyrazinamide and allopurinol.
A 74-year-old female was diagnosed as having xanthinuria by measurement of the uric acid level in plasma, purine bases in urine… 
1989
1989
Hereditary xanthine oxidase deficiency consisting of at least two subgroups.
Previous studies1–6 indicated that though pyrazinamide was metabolized into 5-hydroxypyrazinamide, its deamidated form… 
1987
1987
Metabolic disposition of pyrazinamide in the rat: identification of a novel in vivo metabolite common to both rat and human.
Only limited studies have been reported on the disposition and pharmacokinetics of pyrazinamide (PZA) in both animals and humans… 
1987
1987
[Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].
The method reported here for determining pyrazinamide and its metabolites (2-pyrazinoic acid, 5-hydroxypyrazinamide, 5… 
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