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Amiloride Hydrochloride

Known as: N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide Monohydrochloride, Pyrazinecarboxamide, N-Amidino-3,5-diamino-6-chloro-, Monohydrochloride, Hydrochloride, Amiloride 
The hydrochloride salt of amiloride, a synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels… 
National Institutes of Health

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16 relations
AmilorideAnuriaCystic FibrosisDecreased Blood Pressure [PE]

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Papers overview

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1997
1997
Temperature and amiloride alter taste nerve responses to Na+, K+, and NH4 + salts in rats
Highly Cited
1995
Highly Cited
1995
Sodium intake linked to amiloride-sensitive gustatory transduction in C57BL/6J and 129/7 mice
Highly Cited
1992
Highly Cited
1992
Suppression of human alveolar macrophage-derived cytokines by amiloride.
Various human alveolar macrophage (AM)-derived cytokines in the lungs have been shown to be present under conditions of normal… 
Highly Cited
1990
Highly Cited
1990
Perceptual characteristics of the amiloride-suppressed sodium chloride taste response in the rat.
The contribution of amiloride-sensitive membrane components to the perception of NaCl taste was assessed by using a conditioned… 
1988
1988
Amiloride sensitive activation of S6 kinase by angiotensin II in cultured vascular smooth muscle cells.
Highly Cited
1987
Highly Cited
1987
Amiloride-sensitive sodium channels and expression of sodium appetite in rats.
Lingual application of amiloride hydrochloride blocks a sodium transport system in the mammalian gustatory system. Effects of… 
1981
1981
Mechanism of Action, Pharmacokinetics, Adverse Effects, and Therapeutic Uses of Amiloride Hydrochloride, A New Potassium‐Sparing Diuretic
Amiloride hydrochloride is a new, orally administered, potassium‐sparing diuretic with mild natriuretic and diuretic properties… 
Highly Cited
1969
Highly Cited
1969
The metabolism of amiloride hydrochloride in man
Amiloride hydrochloride labeled with C14 was given to 5 volunteers. Serum level peaked at 3 hours, and the half‐life was 6 hours… 
1968
1968
Amiloride hydrochloride in hypertensive patients.
In man amiloride hydrochloride (MK-870) has been shown to be an orally effective diuretic which causes a positive potassium… 
Highly Cited
1967
Highly Cited
1967
The potassium-sparing and natriuretic activity of N-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate (amiloride hydrochloride).
N-amidino-3-amino-6-chloropyrazinecarboxamide enhanced Na+ excretion and decreased K+ excretion in normal and adrenalectomized… 
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