• Publications
  • Influence
The left lung from a dog was removed, ventilated with negative pressure, and perfused with venous blood. Pulmonary arterial, venous, and alveolar pressures could be varied over a large range. The d...
  • 937
  • 30
  • PDF
Human gene for physical performance
A specific genetic factor that strongly influences human physical performance has not so far been reported, but here we show that a polymorphism in the gene encoding angiotensin-converting enzymeExpand
  • 546
  • 23
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.
BACKGROUND Isolated systolic hypertension occurs in about 15% of people aged 60 years or older. In 1989, the European Working Party on High Blood Pressure in the Elderly investigated whether activeExpand
  • 684
  • 16
Absorption and metabolism of nicotine from cigarettes.
Eight men volunteers each smoked a single cirgarette containing 14C-nicotine and gave arterial blood samples during and for 50 minutes after smoking. The maximum concentration of nicotine in theExpand
  • 312
  • 10
  • PDF
IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels
The IUPHAR database integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand- gated ion channel subunits and 141 voltage-gated-like ion channels encoded by the human, rat and mouse genomes. Expand
  • 197
  • 9
  • PDF
The Retinal Circulation
  • 286
  • 5
Absorption of nicotine from small cigars
The absorption of nicotine from cigars was measured in 7 male subjects who each smoked a single small cigar containing 14C‐nicotine. The proportion of nicotine in the mainstream smoke delivered toExpand
  • 41
  • 5
Distribution of blood flow and ventilation-perfusion ratio in the lung, measured with radioactive CO2
Inhaled radioactive CO2 is rapidly taken up by pulmonary blood. By external counting over the chest during breath holding, the clearance rate of radioactive CO2xs from the counting field can be rec...
  • 401
  • 4
Effect of cysteinyl-leukotriene receptor antagonist ICI 204.219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects
The effects of a highly selective leukotriene D4 receptor antagonist, ICI 204.219, on allergen-induced bronchoconstriction and changes in airway reactivity were evaluated in a double-blind,Expand
  • 451
  • 4
Heparin Kinetics in Venous Thrombosis and Pulmonary Embolism
The response to a standard dose of heparin was studied in 20 patients with venous thromboembolism. The heparin regimen consisted of intravenous injection of 70 units per kg, followed after 90 minutesExpand
  • 273
  • 4