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Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis.
TLDR
PBEF is identified as a novel inflammatory cytokine that plays a requisite role in the delayed neutrophil apoptosis of clinical and experimental sepsis and is also upregulated in neutrophils by IL-1beta and functions as an inhibitor of apoptosis in response to a variety of inflammatory stimuli. Expand
Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin.
TLDR
It is shown that TGF-beta 1 was unable to induce EMT in intact confluent monolayers, but three different models of injury-induced loss of epithelial integrity restored its EMT-inducing effect, suggesting a beta-catenin-dependent two-hit mechanism in which both an initial epithelial injury and TGF 1 are required for EMT. Expand
Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition.
TLDR
Rho plays a dual role in TGF-beta(1)-induced EMT of renal epithelial cells, indispensable both for cytoskeleton remodeling and for the activation of the SMA promoter. Expand
Phagosomal acidification is mediated by a vacuolar-type H(+)-ATPase in murine macrophages.
TLDR
The substrate requirement and inhibitor susceptibility profile of phagosomal acidification strongly suggest that proton translocation across the phagosome to cytosol pH gradient is mediated by a vacuolar-type H(+)-ATPase. Expand
Hemorrhagic shock primes for increased expression of cytokine-induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide.
TLDR
Findings show that augmented release of CINC, in part from primed alveolar macrophages, contributes significantly to the enhanced lung leukosequestration and transpulmonary albumin flux in response to LPS following resuscitated shock. Expand
GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.
TLDR
The ERK/GEF-H1/Rho/ Rho kinase/phospho-MLC pathway is identified as the mechanism mediating TNF-alpha-induced elevation of tubular epithelial permeability, which in turn might contribute to kidney injury. Expand
A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages
TLDR
Comparison of the magnitude of the current with the amount of metabolic acid generated during macrophage activation indicates that the conductance is sufficiently large to contribute to the H+ extrusion required for maintenance of pHi. Expand
Modeling the two-hit hypothesis for evaluating strategies to prevent organ injury after shock/resuscitation.
TLDR
The rationale underlying the use of a "two-hit" model in trauma research is reviewed and a specific example is cited and these models permit investigation aimed at understanding the cellular and molecular mechanisms of disease after shock/resuscitation. Expand
Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial
TLDR
Primary and retrospective analyses of efficacy suggest that treatment with rhIL-1ra results in a dose-related increase in survival time among patients with sepsis who have organ dysfunction and/or a predicted risk of mortality of 24% or greater. Expand
Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance.
TLDR
CD36-dependent binding and signaling appears to be crucial for the nonopsonic clearance of PEs and does not appear to contribute to the increase in TNF-alpha that is prognostic of poor outcome in clinical malaria. Expand
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