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The contribution of epithelial sodium channels to alveolar function in health and disease.
- D. Eaton, My N. Helms, Michael Koval, H. Bao, L. Jain
- BiologyAnnual review of physiology
- 12 February 2009
Lung epithelium has enormous flexibility to alter the magnitude of salt and water transport and regulation depends upon the type of sodium channel but involves controlling the number of apical channels and/or the activity of individual channels.
Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport.
- Meshell D. Johnson, H. Bao, D. Eaton
- BiologyProceedings of the National Academy of Sciences…
- 28 March 2006
The findings of this work lead to a revised paradigm of ion and water transport in the lung in which (i) Na(+) and Cl(-) transport occurs across the entire alveolar epithelium (TI and TII cells) rather than only across T II cells; and (ii) by virtue of their very large surface area, TI cells are responsible for the bulk of transepithelial Na(+).
Physiology of fetal lung fluid clearance and the effect of labor.
The physiologic mechanisms underlying fetal lung fluid absorption are discussed and potential strategies for facilitating neonatal transition are explored.
Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions.
- L. Jain, X. Chen, S. Ramosevac, L. Brown, D. Eaton
- BiologyAmerican journal of physiology. Lung cellular and…
- 1 April 2001
Results show that when grown on permeable supports in the presence of steroids and air interface, the predominant channels expressed in ATII cells have single-channel characteristics resembling channels that are associated with the coexpression of the three cloned ENaC subunits alpha-, beta-, and gamma-ENaC.
Phosphatidylinositol 4,5-Bisphosphate (PIP2) Stimulates Epithelial Sodium Channel Activity in A6 Cells*
Results indicate that PIP2 increases ENaC activity by direct interaction with β or γ xENaC in the presence of Gαi-3, which is similar to that of 30 μm PIP 2 plus 100 μm GTP.
Vander's Renal Physiology
This text explores the fundamental aspects of renal physiology that are essential for an understanding of clinical medicine and offers the best review for the USMLE Step 1.
Effects of vasopressin and cAMP on single amiloride-blockable Na channels.
It is suggested that pretreatment of cells with vasopressin, DBcAMP, or CTX may act by promoting insertion of clusters of new sodium channels in membrane patches.
Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia.
It cannot be demonstrated statistically that ald testosterone removal reduces the number of channels per patch, and there may actually be up to a twofold increase after a long period of aldosterone depletion, rather than promotion of the appearance or disappearance of channels from the membrane.
Influenza virus inhibits ENaC and lung fluid clearance.
- Xi-Juan Chen, S. Seth, L. Jain
- Biology, MedicineAmerican journal of physiology. Lung cellular and…
- 30 April 2004
Results show that influenza virus rapidly inhibits ENaC in ATII cells via a PLC- and Src-mediated activation of PKC but does not increase epithelial permeability in this same rapid time course, which is speculated to facilitate subsequent influenza infection and may exacerbate influenza-mediated alveolar flooding that can lead to acute respiratory failure and death.
Role of SGK1 in nitric oxide inhibition of ENaC in Na+-transporting epithelia.
- My N. Helms, Ling Yu, B. Malik, D. Kleinhenz, C. Hart, D. Eaton
- BiologyAmerican journal of physiology. Cell physiology
- 1 September 2005
iNOS is identified as a novel SGK1 phosphorylated protein (at S733 and S903 residues in miNOS) suggesting that one way in which SGK 1 could increase Na(+) transport is by altering iNOS production of NO.