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Affinity Reagent

In chemistry and biology, a compound that binds specific substances, such as proteins or nucleic acids. Many affinity reagents are antibodies. They… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Significance Despite the high antigenic diversity of the HIV envelope trimer (Env), broadly neutralizing antibodies (bnAbs) have… Expand
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Highly Cited
2013
Highly Cited
2013
Affinity purification coupled with mass spectrometry (AP-MS) is a widely used approach for the identification of protein-protein… Expand
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Highly Cited
2013
Highly Cited
2013
Lysine methylation of histone proteins regulates chromatin dynamics and plays important roles in diverse physiological and… Expand
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Highly Cited
2009
Highly Cited
2009
We herein demonstrate a sandwich assay based on single aptamer sequences is suitable for the direct detection of small molecule… Expand
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Review
2007
Review
2007
Essential to the ambition of characterising fully the human proteome are systematic and comprehensive collections of specific… Expand
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Highly Cited
2002
Highly Cited
2002
To identify human proteins that bind to the Smac and caspase-9 binding pocket on the baculoviral inhibitor of apoptosis protein… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Biologically active natural products continue to be useful in the exploration and control of intracellular signaling… Expand
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Highly Cited
2001
Highly Cited
2001
Phosphatidic acid (PA) is an important bioactive lipid, but its molecular targets remain unknown. To identify such targets, we… Expand
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Highly Cited
1994
Highly Cited
1994
Pre-mRNA is processed as a large complex of pre-mRNA, snRNPs and pre-mRNA binding proteins (hnRNP proteins). The significance of… Expand
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Highly Cited
1990
Highly Cited
1990
The c-kit proto-oncogene, the gene at the mouse W developmental locus, is one of a substantial group of genes that appear to… Expand
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