• Publications
  • Influence
Carbohydrate-specific receptors of the liver.
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Challenges and opportunities in cancer control in Africa: a perspective from the African Organisation for Research and Training in Cancer.
Sub-Saharan Africa has a disproportionate burden of disease and faces a major public-health challenge from non-communicable diseases. Although infectious diseases continue to afflict Africa, theExpand
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Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.
The biosynthetic rates for both the transferrin receptor (TfR) and ferritin are regulated by iron. An iron-responsive element (IRE) in the 5' untranslated portion of the ferritin messenger RNA (mRNA)Expand
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Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.
The binding of apotransferrin to the transferrin receptor on the surface of human leukemic K562 cells was found to be significantly less tight than that of the holoprotein, diferric transferrin. TheExpand
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Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.
The stability of transferrin receptor (TfR) mRNA is regulated by iron availability. When a human plasma‐cytoma cell line (ARH‐77) is treated with an iron source (hemin), the TfR mRNA is destabilizedExpand
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Guideline implementation for breast healthcare in low‐income and middle‐income countries
Breast cancer outcomes in low‐ and middle‐income countries (LMCs) correlate with the degree to which 1) cancers are detected at early stages, 2) newly detected cancers can be diagnosed correctly, andExpand
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Breast-cancer early detection in low-income and middle-income countries: do what you can versus one size fits all.
  • J. Harford
  • Medicine
  • The Lancet. Oncology
  • 1 March 2011
In general, rates of breast cancer are lower in low-income and middle-income countries (LMCs) than they are in more industrialised countries of North America and Europe. This lower incidence meansExpand
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Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.
At physiological temperature, the Fe-carrier transferrin is taken up by K562 human erythroleukemia cells through receptor-mediated endocytosis. Both ligand (now minus Fe) and receptor recycle back toExpand
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Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.
Regulated translation of messenger RNA offers an important mechanism for the control of gene expression. The biosynthesis of the intracellular iron storage protein ferritin is translationallyExpand
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