J. Harford

Publications171
h-index59
Citations14,240
Highly Influential Citations273
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Regulating the fate of mRNA: The control of cellular iron metabolism
Carbohydrate-specific receptors of the liver.
Challenges and opportunities in cancer control in Africa: a perspective from the African Organisation for Research and Training in Cancer.
Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.
TLDR
The 3' untranslated region of the mRNA for the human TfR was shown to be necessary and sufficient for iron-dependent control of mRNA levels and an mRNA element has been implicated in the mediation of distinct regulatory phenomena dependent on the context of the element within the transcript.
Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.
TLDR
A mechanism to account for the recycling of transferrin subsequent to internalization and residence within an acidic nonlysosomal organelle where iron is removed is proposed.
Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.
TLDR
Site‐directed mutagenesis demonstrates that the sequence surrounding the mapped endonuclease cleavage site is required for both iron‐regulated mRNA turnover and generation of the truncated degradation intermediate of the transferrin receptor mRNA.
Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.
TLDR
In this report the iron-responsive element (IRE) was identified by deletional analysis and a synthetic oligodeoxynucleotide was shown to be able to transfer iron regulation to a construct that would otherwise not been able to respond to iron.
Guideline implementation for breast healthcare in low‐income and middle‐income countries
TLDR
Focus groups addressed specific issues in breast pathology, radiation therapy, and management of locally advanced disease and indicated that cancer prevention through health behavior modification could influence breast cancer incidence in LMCs.
The age‐specific prevalence of human papillomavirus and risk of cytologic abnormalities in rural Nigeria: Implications for screen‐and‐treat strategies
TLDR
In Irun and similar settings where HPV does not decline with age, HPV‐based screen‐and‐treat programs might be feasible for mid‐adult women because prevalence is sufficiently low and positivity predicts elevated risk of more easily treated precancer.
Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.
TLDR
After endocytosis, transferrin becomes transiently lodged within an acidic compartment inside the cell, as judged by the changed spectral characteristics and quantum yield of fluorescein isothiocyanate-labeled transferrin that is cell-associated at 37 degrees C.
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