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- Publications
- Influence
Regulating the fate of mRNA: The control of cellular iron metabolism
- R. Klausner, T. Rouault, J. Harford
- Biology, Medicine
- Cell
- 15 January 1993
Carbohydrate-specific receptors of the liver.
- G. Ashwell, J. Harford
- Chemistry, Medicine
- Annual review of biochemistry
- 1982
Challenges and opportunities in cancer control in Africa: a perspective from the African Organisation for Research and Training in Cancer.
- I. Morhason-Bello, F. Odedina, +4 authors Isaac F. Adewole
- Geography, Medicine
- The Lancet. Oncology
- 1 April 2013
Sub-Saharan Africa has a disproportionate burden of disease and faces a major public-health challenge from non-communicable diseases. Although infectious diseases continue to afflict Africa, the… Expand
Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.
- J. Casey, M. Hentze, +4 authors J. Harford
- Biology, Medicine
- Science
- 13 May 1988
The biosynthetic rates for both the transferrin receptor (TfR) and ferritin are regulated by iron. An iron-responsive element (IRE) in the 5' untranslated portion of the ferritin messenger RNA (mRNA)… Expand
Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.
- R. Klausner, G. Ashwell, J. van Renswoude, J. Harford, K. Bridges
- Medicine, Chemistry
- Proceedings of the National Academy of Sciences…
- 1 April 1983
The binding of apotransferrin to the transferrin receptor on the surface of human leukemic K562 cells was found to be significantly less tight than that of the holoprotein, diferric transferrin. The… Expand
Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.
- R. Binder, J. A. Horowitz, J. Basilion, D. Koeller, R. Klausner, J. Harford
- Biology, Medicine
- The EMBO journal
- 1 April 1994
The stability of transferrin receptor (TfR) mRNA is regulated by iron availability. When a human plasma‐cytoma cell line (ARH‐77) is treated with an iron source (hemin), the TfR mRNA is destabilized… Expand
Guideline implementation for breast healthcare in low‐income and middle‐income countries
- B. Anderson, C. Yip, +6 authors J. Harford
- Medicine
- Cancer
- 15 October 2008
Breast cancer outcomes in low‐ and middle‐income countries (LMCs) correlate with the degree to which 1) cancers are detected at early stages, 2) newly detected cancers can be diagnosed correctly, and… Expand
Breast-cancer early detection in low-income and middle-income countries: do what you can versus one size fits all.
- J. Harford
- Medicine
- The Lancet. Oncology
- 1 March 2011
In general, rates of breast cancer are lower in low-income and middle-income countries (LMCs) than they are in more industrialised countries of North America and Europe. This lower incidence means… Expand
Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.
- J. van Renswoude, K. Bridges, J. Harford, R. Klausner
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 October 1982
At physiological temperature, the Fe-carrier transferrin is taken up by K562 human erythroleukemia cells through receptor-mediated endocytosis. Both ligand (now minus Fe) and receptor recycle back to… Expand
Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.
- M. Hentze, S. Caughman, +4 authors R. Klausner
- Biology, Medicine
- Science
- 11 December 1987
Regulated translation of messenger RNA offers an important mechanism for the control of gene expression. The biosynthesis of the intracellular iron storage protein ferritin is translationally… Expand