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Thrombosis and haemostasis
Hemostasis and thrombosis: Basic principles and clinical practice
TLDR
Part I - BASIC PRINCIPLES of HEMOSTASIS and THROMBOSIS and CLINICAL APPLICATIONS. Expand
Experimental models of inflammatory bowel disease.
TLDR
The etiology and pathogenesis of inflammatory bowel disease (IBD) remains unsolved, but improved experimental models of enterocolitis have led to progress and generated new hypotheses, expanded human studies, and suggested novel forms of therapy for IBD patients. Expand
Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes.
THE KALLIKREIN-KININ system was first recognized as a plasma and tissue proteolytic system responsible for the liberation of the vasoactive, proinflammatory mediator, bradykinin (BK).[1][1] BK, aExpand
Platelet hypersensitivity induced by cholesterol incorporation.
TLDR
It is demonstrated that the cholesterol content of platelets is dependent on the lipid composition of the milier, and cholesterol acquired by platelets may exert its effect on platelet function by a modification of the platelet membrane. Expand
The regulation of human factor XIIa by plasma proteinase inhibitors.
TLDR
C1INH functions as the predominant inhibitor of factor XIIa in plasma, and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that the complexes in plasma had the same molecular size as those with purified inhibitors. Expand
Thrombin during cardiopulmonary bypass.
TLDR
The routine use of a cell saver and the eventual introduction of direct thrombin inhibitors now offer the possibility of completely suppressing thrombotic production and fibrinolysis during cardiac surgery with CPB. Expand
Are hemostasis and thrombosis two sides of the same coin?
  • R. Colman
  • Medicine
  • The Journal of experimental medicine
  • 20 March 2006
TLDR
Factor XII (FXII), a clotting enzyme that can initiate coagulation in vitro, has long been considered dispensable for normal blood clotting in vivo, but new studies show that mice lacking FXII are protected against arterial thrombosis and stroke. Expand
The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in
TLDR
It is suggested that irreversible hypotension correlates with prolonged activation of the contact system, and specific antibody therapy can modulate both the pathophysiological and biochemical changes. Expand
Domain 5 of high molecular weight kininogen (kininostatin) down-regulates endothelial cell proliferation and migration and inhibits angiogenesis.
TLDR
HK D5 (for which the designation is suggested, "kininostatin") is a potent inhibitor of endothelial cell migration and proliferation in vitro and of angiogenesis in vivo. Expand
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