Thrombosis and haemostasis
- R. Colman, G. Stewart, Jeanette Piperno
- MedicineNature
- 13 December 1979
Hemostasis and thrombosis: Basic principles and clinical practice
- R. Colman
- Medicine
- 1987
Part I - BASIC PRINCIPLES of HEMOSTASIS and THROMBOSIS and CLINICAL APPLICATIONS.
Experimental models of inflammatory bowel disease.
- A. Stadnicki, R. Colman
- BiologyArchivum Immunologiae et Therapiae Experimentalis
- 2003
The etiology and pathogenesis of inflammatory bowel disease (IBD) remains unsolved, but improved experimental models of enterocolitis have led to progress and generated new hypotheses, expanded human studies, and suggested novel forms of therapy for IBD patients.
Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes.
- R. Colman, A. Schmaier
- MedicineBlood
- 15 November 1997
THE KALLIKREIN-KININ system was first recognized as a plasma and tissue proteolytic system responsible for the liberation of the vasoactive, proinflammatory mediator, bradykinin (BK).[1][1] BK, a…
Are hemostasis and thrombosis two sides of the same coin?
- R. Colman
- Medicine, BiologyJournal of Experimental Medicine
- 20 March 2006
Factor XII (FXII), a clotting enzyme that can initiate coagulation in vitro, has long been considered dispensable for normal blood clotting in vivo, but new studies show that mice lacking FXII are protected against arterial thrombosis and stroke.
Platelet hypersensitivity induced by cholesterol incorporation.
- S. Shattil, R. Anaya-Galindo, J. Bennett, R. Colman, R. A. Cooper
- Biology, MedicineJournal of Clinical Investigation
- 1 March 1975
It is demonstrated that the cholesterol content of platelets is dependent on the lipid composition of the milier, and cholesterol acquired by platelets may exert its effect on platelet function by a modification of the platelet membrane.
The regulation of human factor XIIa by plasma proteinase inhibitors.
- R. Pixley, M. Schapira, R. Colman
- BiologyJournal of Biological Chemistry
- 10 February 1985
The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in…
- R. Pixley, R. A. de la Cadena, R. Colman
- Biology, MedicineJournal of Clinical Investigation
- 1993
It is suggested that irreversible hypotension correlates with prolonged activation of the contact system, and specific antibody therapy can modulate both the pathophysiological and biochemical changes.
Regulation of angiogenesis by the kallikrein-kinin system.
- R. Colman
- BiologyCurrent pharmaceutical design
- 30 June 2006
In vivo, mAb C11C1 inhibits tumor angiogenesis in mice as well as in experimental inflammatory arthritis and inflammatory bowel disease in Lewis rats and in vitro HKa or D5 inhibits endothelial cell adhesion to vitronectin and fibrinogen, resulting in anokis and apoptosis.
Thrombin during cardiopulmonary bypass.
- L. Edmunds, R. Colman
- Medicine, BiologyAnnals of Thoracic Surgery
- 1 December 2006
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