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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
The development of human cancer is a multistep process characterized by the accumulation of genetic and epigenetic alterations that drive or reflect tumour progression. These changes distinguish… Expand
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction… Expand
Endocytosis and molecular sorting.
- I. Mellman
- Biology, Medicine
- Annual review of cell and developmental biology
Endocytosis in eukaryotic cells is characterized by the continuous and regulated formation of prolific numbers of membrane vesicles at the plasma membrane. These vesicles come in several different… Expand
Acidification of the endocytic and exocytic pathways.
AND PERSPECTIVES 664 THE ORGANEL L ES OF THE EXOAND ENDOCYTIC PATHWAyS . . . . . . . . . . . . . ..... 665 The Endocytic Pathway . . . . . . . . . . . . . . . . . . . . . . . . .. . . ... . . . . . .… Expand
Oncology meets immunology: the cancer-immunity cycle.
The genetic and cellular alterations that define cancer provide the immune system with the means to generate T cell responses that recognize and eradicate cancer cells. However, elimination of cancer… Expand
Cancer immunotherapy comes of age
Activating the immune system for therapeutic benefit in cancer has long been a goal in immunology and oncology. After decades of disappointment, the tide has finally changed due to the success of… Expand
The Receptor Recycling Pathway Contains Two Distinct Populations of Early Endosomes with Different Sorting Functions
Receptor recycling involves two endosome populations, peripheral early endosomes and perinuclear recycling endosomes. In polarized epithelial cells, either or both populations must be able to sort… Expand
Elements of cancer immunity and the cancer–immune set point
Immunotherapy is proving to be an effective therapeutic approach in a variety of cancers. But despite the clinical success of antibodies against the immune regulators CTLA4 and PD-L1/PD-1, only a… Expand
Dendritic Cells Specialized and Regulated Antigen Processing Machines
cells are adept at endocytosis and express relatively low levels of surface MHC class I and II products and costimu-latory molecules (e.g., CD86). Abundant MHC class II molecules are synthesized, but… Expand
TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancers, including… Expand