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Mechanism of inhibition of aldehyde dehydrogenase by citral, a retinoid antagonist.
Low concentrations of citral (3,7-dimethyl-2,6-octadienal), an inhibitor of retinoic acid biosynthesis, inhibited E1, E2 and E3 isozymes of human aldehyde dehydrogenase (EC1.2.1.3). The inhibitionExpand
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Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes.
Human liver extracts show two major bands with aldehyde dehydrogenase (Aldehyde:NAD+ oxidoreductase, EC activity via starch gel electrophoresis at pH 7.0. Both bands have been purified toExpand
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Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram.
Disulfiram labeled with carbon-14 reacts specifically with human liver aldehyde dehydrogenase E1 with loss of catalytic activity and no incorporation of label. Carbon-14-labeledExpand
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Human aldehyde dehydrogenase E3 isozyme is a betaine aldehyde dehydrogenase.
The E3 isozyme of human aldehyde dehydrogenase (EC, with broad substrate specificity, which also catalyzes dehydrogenation of 4-aminobutyraldehyde, was purified and sequenced recently (1,3).Expand
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Purification and characterization of human liver "high Km" aldehyde dehydrogenase and its identification as glutamic gamma-semialdehyde dehydrogenase.
The enzyme previously considered as an isozyme (E4, ALDH IV) of human liver aldehyde dehydrogenase (NAD+) (EC has been purified to homogeneity by the use of ion exchange chromatography onExpand
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Methylglyoxal as substrate and inhibitor of human aldehyde dehydrogenase: comparison of kinetic properties among the three isozymes.
Methylglyoxal was demonstrated to be a substrate for the isozymes E1, E2 and E3 of human aldehyde dehydrogenase. Pyruvate was the product from the oxidation of methylglyoxal by the three isozymes. AtExpand
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Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+ -dependent succinic semialdehyde dehydrogenase.
NAD-dependent succinic semialdehyde dehydrogenase (EC has been purified to homogeneity from human brain via ion-exchange chromatography and affinity chromatography employing Blue SepharoseExpand
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Human aldehyde dehydrogenase. Activity with aldehyde metabolites of monoamines, diamines, and polyamines.
Two isozymes (E1 and E2) of human aldehyde dehydrogenase (EC were purified to homogeneity 13 years ago and a third isozyme (E3) with a low Km for gamma-aminobutyraldehyde only recently.Expand
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Comparison of substrate specificity of alcohol dehydrogenases from human liver, horse liver, and yeast towards saturated and 2-enoic alcohols and aldehydes.
The saturated and 2-enoic primary alcohols and aldehydes, ethanol, 1-propanol, 1-butanol, 3-methyl-1-butanol, 1-hexanol, phenylmethanol, 3-phenyl-1-propanol, 2-propen-1-ol, 2-buten-1-ol,Expand
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Aldehyde dehydrogenase isozymes.
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