ARHGEF7 gene

Known as: BETA-PIX, PIXB, DKFZp686C12170 
This gene plays a role in apoptosis and GTPase-mediated signaling.
National Institutes of Health

Related topics

Related topics

6 relations
ARHGEF15 genePositive Regulation of ApoptosisRho Guanine Nucleotide Exchange Factor 7, humanRho guanine nucleotide exchange factor 7
(More)

Narrower (1)

ARHGEF7 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7
LRRK2, a gene relevant to Parkinson's disease, encodes a scaffolding protein with both GTPase and kinase activities. LRRK2… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
A meta-analysis of P50 studies in patients with schizophrenia and relatives: Differences in methodology between research groups
OBJECTIVE To determine whether patients with schizophrenia as well as their relatives show deficits in sensory gating reflected… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages.
Lipopolysaccharide (LPS) induces expression of tumor necrosis factor alpha (TNFalpha) and other pro-inflammatory cytokines in… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.
Apoptotic pathways and DNA synthesis are activated in neurons in the brains of individuals with Alzheimer disease (AD). However… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein beta (C/EBP beta) and Rel p50.
We have previously found that overexpression of the Rel protein p50 stimulated C-reactive protein (CRP) expression in Hep 3B… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment.
Fas (CD95) and Fas ligand (CD95L) are an interacting receptor-ligand pair required for immune homeostasis. Lymphocyte activation… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function.
Genetic screens in Drosophila have identified p50(cdc37) to be an essential component of the sevenless receptor/mitogen-activated… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA
The NF-κB p50/p65 heterodimer is the classical member of the Relfamily of transcription factors which regulate diverse cellular… (More)
  • table 1
  • figure 1
  • figure 3
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Chronic Inflammation and Susceptibility to Bacterial Infections in Mice Lacking the Polypeptide (p)105 Precursor (NF-κB1) but Expressing p50
The polypeptide (p)50 molecule, a subunit of nuclear factor (NF)-kappaB, is produced after proteolytic processing of the p105… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.
Stimulation of the human monocytic cell line Mono Mac 6 with lipopolysaccharide (LPS) leads to rapid and transient expression of… (More)
Is this relevant?