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Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
TLDR
Treatment with a novel potent PARP inhibitor, starting after the time of islet destruction, maintained normal vascular responsiveness, despite the persistence of severe hyperglycemia, indicating that PARP may be a novel drug target for the therapy of diabetic endothelial dysfunction. Expand
Adenosine inhibits IL‐12 and TNF‐α production via adenosine A2a receptor‐dependent and independent mechanisms
TLDR
The notion that adenosinebased therapies might be useful in certain autoimmune and/or inflammatory diseases is supported, as the effect of the endogenous purine nucleosideadenosine on the production of IL‐12 was investigated. Expand
The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes.
TLDR
Treatment with a novel potent phenanthridinone-based PARP inhibitor, PJ34, starting 1 week after the onset of diabetes, restored normal vascular responsiveness and significantly improved cardiac dysfunction, despite the persistence of severe hyperglycemia. Expand
Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock1
TLDR
Inosine suppressed proinflammatory cytokine production and mortality in a mouse endotoxemic model and suggests that this agent may be useful in the treatment of inflammatory/ischemic diseases. Expand
Potent Metalloporphyrin Peroxynitrite Decomposition Catalyst Protects Against the Development of Doxorubicin-Induced Cardiac Dysfunction
TLDR
Peroxynitrite plays a key role in the pathogenesis of DOX-induced cardiac failure and may represent a new cardioprotective strategy after DOX exposure or in other conditions associated with peroxynite formation, including myocardial ischemia/reperfusion injury. Expand
Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation.
TLDR
The absence of functional PARP-1 reduced LPS-induced increases of cytokines and chemokines, alveolar neutrophil accumulation, lung hyperpermeability, NO production, and lipid peroxidation, and Histological analysis revealed attenuated lung damage after PARP inhibition. Expand
Potential role for 8‐oxoguanine DNA glycosylase in regulating inflammation
TLDR
It is found that OGG‐1−/− mice are resistant to endotoxin (lipopolysaccharide, LPS)‐induced organ dysfunction, neutrophil infiltration and oxidative stress, when compared with the response seen in wild‐type controls (OGG+/+). Expand
Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst
TLDR
In diabetic NOD mice, a 7‐day treatment with either 1 or 3 mg kg−1 d−1 FP15 reversed increased tail‐flick latency (a sign of reduced pain sensitivity); the effect of the higher dose was significant as early as 3 days after beginning of the treatment. Expand
Adenosine receptor activation ameliorates type 1 diabetes
TLDR
The results demonstrate that adenosine receptor ligands are potential candidates for the treatment of type 1 diabetes and are demonstrated to be beneficial due to immunomodulation. Expand
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.
TLDR
This review focuses on the role of nitrosative stress and downstream mechanisms including activation of PARP in diabetic complications and on novel emerging therapeutical strategies offered by neutralization of peroxynitrite and inhibition ofPARP. Expand
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