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Rho Guanine Nucleotide Exchange Factor 7, human

Known as: COOL-1, Rho Guanine Nucleotide Exchange Factor 7, p85 
Rho guanine nucleotide exchange factor 7 (803 aa, ~90 kDa) is encoded by the human ARHGEF7 gene. This protein plays a role in both the modulation of… 
National Institutes of Health

Papers overview

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2019
2019
Glioblastoma multiforme (GBM) is the most common aggressive tumor of the central nervous system (CNS) with 10,000 newly diagnosed… 
2014
2014
We discovered that glioblastoma (GBM) cells use Cool‐1/β‐pix to inhibit normal activation of the c‐Cbl ubiquitin ligase via the… 
2013
2013
Glioblastomas (GBMs), the most malignant glial tumors, differ from normal glial progenitor cells in many ways, but little is… 
2010
2010
Previously we showed that Cool-1 (Cloned out of library-1)/β-Pix (Pak-interactive exchange factor) is phosphorylated at a… 
Highly Cited
2006
Highly Cited
2006
Cool-1 (cloned-out of library 1) has a key role in regulating epidermal growth factor receptor (EGFR) degradation. Here, we show… 
2006
2006
Cool-1 was previously identified as an effector of activated Cdc42 and as a regulator of epidermal growth factor receptor (EGFR… 
Highly Cited
2004
Highly Cited
2004
The Ras-related GTPase Rap1 stimulates integrin-mediated adhesion and spreading in various mammalian cell types. Here, we… 
Highly Cited
2004
Highly Cited
2004
2003
2003
Members of the Rho GTPase family are key regulatory molecules that link surface receptors to the organization of the actin…