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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
▪ Abstract The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it…
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The NF-kappa B and I kappa B proteins: new discoveries and insights.
TLDR
Excitement in NF-kappa B research has been generated by the first report of a crystal structure for one form of NF-Kappa B, the first gene knockout studies for different forms ofNF-kB and of I kappaB, and the implications for therapies of diseases thought to involve the inappropriate activation of NF.
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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.
Tumor necrosis factor alpha (TNF-alpha) binding to the TNF receptor (TNFR) potentially initiates apoptosis and activates the transcription factor nuclear factor kappa B (NF-kappaB), which suppresses…
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NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
TLDR
It is shown that NF-κB also promotes cell growth in embryonic fibroblasts, correlating with its regulation of cyclin D1, and is identified as an important transcriptional target of NF-α, revealing a mechanism to explain how NF-β is involved in the early phases of the cell cycle to regulate cell growth and differentiation.
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TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
TLDR
The activation of the transcription factor nuclear factor-kappa B by tumor necrosis factor, ionizing radiation, or daunorubicin, was found to protect from cell killing, providing a mechanism of cellular resistance to killing by some apoptotic reagents.
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Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38*
TLDR
It is demonstrated that Akt, functioning through IκB kinase and p38, induces the transcription function of NF-κB by stimulating the RelA/p65 transactivation subunit of NF -κB.
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NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia.
TLDR
The role of NF-kappaB in cytokine-induced muscle degeneration was explored and its expression was down-regulated by TNF and IFN-gamma expression in mouse muscle in vivo, elucidate a possible mechanism that may underlie the skeletal muscle decay in cachexia.
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The p65 (RelA) Subunit of NF-κB Interacts with the Histone Deacetylase (HDAC) Corepressors HDAC1 and HDAC2 To Negatively Regulate Gene Expression
TLDR
The results show that inhibition of HDAC activity with trichostatin A (TSA) results in an increase in both basal and induced expression of an integrated NF-κB-dependent reporter gene, and suggests that the association of NF-σκB with the HDAC1 and HDAC2 corepressor proteins functions to repress expression ofNF-κBsregulated genes as well as to control the induced level of expression of these genes.
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Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
TLDR
It is suggested that the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD and specific pharmacological inhibition of IKK resulted in improved pathology and muscle function in mdx mice.
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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB.
TLDR
The activation of the transcription factor nuclear factor-kappa B by tumor necrosis factor, ionizing radiation, or daunorubicin, was found to protect from cell killing, providing a mechanism of cellular resistance to killing by some apoptotic reagents.
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