Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
- A. Baldwin
- Biology
- 1996
▪ Abstract The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it… Expand
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.
- C. Wang, M. Mayo, R. Korneluk, D. Goeddel, A. Baldwin
- Biology, Medicine
- Science
- 11 September 1998
Tumor necrosis factor alpha (TNF-alpha) binding to the TNF receptor (TNFR) potentially initiates apoptosis and activates the transcription factor nuclear factor kappa B (NF-kappaB), which suppresses… Expand
The NF-kappa B and I kappa B proteins: new discoveries and insights.
- A. Baldwin
- Medicine
- Annual review of immunology
- 1996
The transcription factor NF-kappa B has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it… Expand
NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
- D. Guttridge, C. Albanese, J. Y. Reuther, R. Pestell, A. Baldwin
- Biology, Medicine
- Molecular and Cellular Biology
- 1 August 1999
ABSTRACT Accumulating evidence implicates the transcription factor NF-κB as a positive mediator of cell growth, but the molecular mechanism(s) involved in this process remains largely unknown. Here… Expand
Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38*
- L. V. Madrid, M. Mayo, J. Y. Reuther, A. Baldwin
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 1 June 2001
The serine/threonine kinase Akt/PKB is a potent regulator of cell survival and has oncogenic transformation potential. Previously, it has been shown that Akt can activate the transcription factor… Expand
NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia.
- D. Guttridge, M. Mayo, L. V. Madrid, C. Wang, A. Baldwin
- Biology, Medicine
- Science
- 29 September 2000
MyoD regulates skeletal muscle differentiation (SMD) and is essential for repair of damaged tissue. The transcription factor nuclear factor kappa B (NF-kappaB) is activated by the cytokine tumor… Expand
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
- C. Y. Wang, M. Mayo, A. Baldwin
- Biology
- Science
- 1 November 1996
Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF-κB) by tumor… Expand
The p65 (RelA) Subunit of NF-κB Interacts with the Histone Deacetylase (HDAC) Corepressors HDAC1 and HDAC2 To Negatively Regulate Gene Expression
- B. Ashburner, S. Westerheide, A. Baldwin
- Biology, Medicine
- Molecular and Cellular Biology
- 15 October 2001
ABSTRACT Regulation of NF-κB transactivation function is controlled at several levels, including interactions with coactivator proteins. Here we show that the transactivation function of NF-κB is… Expand
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
- Swarnali Acharyya, S. A. Villalta, +14 authors D. Guttridge
- Biology, Medicine
- The Journal of clinical investigation
- 2 April 2007
Duchenne muscular dystrophy (DMD) is a lethal X-linked disorder associated with dystrophin deficiency that results in chronic inflammation and severe skeletal muscle degeneration. In DMD mouse models… Expand
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
- A. Baldwin
- Biology, Medicine
- The Journal of clinical investigation
- 1 February 2001
The transcription factor NF-κB is well established as a regulator of genes encoding cytokines, cytokine receptors, and cell adhesion molecules that drive immune and inflammatory responses (1). More… Expand