• Publications
  • Influence
RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and Its Inhibiting Cancer Cell Motility*
Background: RhoGDI affects biological activities of small Rho GTPases, leading to regulation of actin polymerization and cell motility. Results: RhoGDI SUMOylation at Lys-138 was crucial for theExpand
  • 53
  • 7
A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition
p27Kip1 is a potent inhibitor of cyclin-dependent kinases that drive G1-to-S cell-cycle transition. Reduced p27Kip1 expression is prevalent in a wide range of human tumours; however, the exactExpand
  • 20
  • 4
  • PDF
X-linked Inhibitor of Apoptosis Protein (XIAP) Mediates Cancer Cell Motility via Rho GDP Dissociation Inhibitor (RhoGDI)-dependent Regulation of the Cytoskeleton*
X-linked inhibitor of apoptosis protein (XIAP) overexpression has been found to be associated with malignant cancer progression and aggression in individuals with many types of cancers. However, theExpand
  • 67
  • 3
The Chinese Herb Isolate Isorhapontigenin Induces Apoptosis in Human Cancer Cells by Down-regulating Overexpression of Antiapoptotic Protein XIAP*
Background: The anti-cancer activity and mechanisms of isorhapontigenin (ISO) have never been explored. Results: ISO exhibited an anti-cancer activity accompanied by apoptotic induction and XIAPExpand
  • 46
  • 3
The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target.
Nuclear factor-kappaB (NF-kappaB) is a key transcriptional factor family that consists of five members in mammalian cells, including NF-kappaB1 (p50), NF-kappaB2 (p52), RelA (p65), RelB and c-Rel.Expand
  • 35
  • 3
Hexavalent Chromium Cr(VI) Up-Regulates COX-2 Expression through an NFκB/c-Jun/AP-1–Dependent Pathway
Background: Hexavalent chromium [Cr(VI)] is recognized as a human carcinogen via inhalation. However, the molecular mechanisms by which Cr(VI) causes cancers are not well understood. Objectives: WeExpand
  • 24
  • 2
  • PDF
NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression
NF-κB is a well-known transcription factor in regulation of multiple gene transcription and biological processes, and most of them are relied on its transcriptional activity of the p65/RelA subunit,Expand
  • 37
  • 2
  • PDF
Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression
Hypoxia-inducible factor-1α (HIF-1α) has been reported to regulate over 100 gene expressions in response to hypoxia and other stress conditions. In the present study, we found that arsenite couldExpand
  • 16
  • 2
The Biological Functions of NF-κB1 (p ) and its Potential as an Anti-Cancer Target
Nuclear factor-κB (NF-κB) is a key transcriptional factor family that consists of five members in mammalian cells, including NF-κB1 (p ), NF-κB2 (p ), RelA (p ), RelB and c-Rel. NF-κB is implicatedExpand
  • 60
  • 1
Divergent behaviors and underlying mechanisms of cell migration and invasion in non-metastatic T24 and its metastatic derivative T24T bladder cancer cell lines
Previous studies on cancer cell invasion were primarily focused on its migration because these two events were often considered biologically equivalent. Here we found that T24T cells exhibited higherExpand
  • 41
  • 1
  • PDF