Skip to search formSkip to main contentSkip to account menu

ABCB11 protein, human

Known as: ABC member 16, MDR-TAP subfamily protein, human, sister of P-glycoprotein protein, human, Bile Salt Export Pump 
Bile salt export pump (1321 aa, ~146 kDa) is encoded by the human ABCB11 gene. This protein plays a role in bile salt secretion.
National Institutes of Health

Related topics

Related topics

19 relations
ABCB11 geneATP HydrolysisAdenosine TriphosphatasesCellular Membrane

Broader (1)

ATP-Binding Cassette Transporters

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
The liver in sepsis
Severe sepsis and septic shock remain a thorny issue in public health care because of their high mortality rate, which has been… 
Review
2010
Review
2010
Differences in presentation and progression between severe FIC1 and BSEP deficiencies.
Highly Cited
2008
Highly Cited
2008
Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies
The human hepatoma HepaRG cells are able to differentiate in vitro into hepatocyte-like cells and to express various liver… 
Highly Cited
2006
Highly Cited
2006
CHARACTERIZATION OF TRANSPORT PROTEIN EXPRESSION IN MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) 2-DEFICIENT RATS
Multidrug resistance-associated protein (Mrp) 2-deficient transport-deficient (TR–) rats, together with their transport-competent… 
Highly Cited
2005
Highly Cited
2005
Bile Salt Export Pump (BSEP/ABCB11) Can Transport a Nonbile Acid Substrate, Pravastatin
Pravastatin is a well known 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor. Cumulative studies have shown that pravastatin is… 
Highly Cited
2005
Highly Cited
2005
Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis
Mutations of the bile salt export pump (BSEP) or the multidrug resistance P‐glycoprotein 3 (MDR3) are linked to impaired bile… 
Highly Cited
2004
Highly Cited
2004
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.
Endotoxin-induced cholestasis in rodents is caused by hepatic downregulation of transporters, including the basolateral Na… 
Highly Cited
2003
Highly Cited
2003
Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.
Highly Cited
2003
Highly Cited
2003
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that controls expression of genes involved in… 
Highly Cited
2000
Highly Cited
2000
Expression of the bile salt export pump is maintained after chronic cholestasis in the rat.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)