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ABCB11 gene

Known as: ABCB11, SPGP, ABC16 
This gene plays a role in the secretion of bile salts.
National Institutes of Health

Related topics

Related topics

6 relations
ABCB11 protein, humanATP HydrolysisHomo sapiensIonophore activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
[Study on hepatotoxicity of aqueous extracts of Polygonum multiflorum in rats after 28-day oral administration: cholestasis-related mechanism].
OBJECTIVE To study the effect of aqueous extracts of Polygonum multiflorum (AEPM) on bile acid synthesis, metabolism and transfer… 
2014
2014
Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets?
The aim of the present study was to identify molecular mechanisms involved in liver fat and cholesterol accumulation in… 
2013
2013
Association of variants of ABCB11 with transient neonatal cholestasis
The significance of ABCB11 variants have been studied in some cholestatic diseases, but this is not clear in transient neonatal… 
2008
2008
Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins
The dog bile salt export pump (BSEP; ABCB11) was cloned and expressed in a Sf9 insect cell system. The deduced amino acid… 
Highly Cited
2006
Highly Cited
2006
High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis.
Human ATP-binding cassette transporter ABCB11 (SPGP/BSEP) mediates the elimination of bile salts from liver cells and thereby… 
2006
2006
A new ABCB11 mutation in two Italian children with familial intrahepatic cholestasis
Progressive familial intrahepatic cholestasis (PFIC) syndromes are characterized by defects in transporters of conjugated bile… 
2005
2005
Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2.
2004
2004
Taurocholate transport by hepatic and intestinal bile acid transporters is independent of FIC1 overexpression in Madin–Darby canine kidney cells
Background:  Mutations in the human familial intrahepatic cholestasis gene, FIC1, result in progressive familial intrahepatic… 
2002
2002
Modulating multidrug resistance: can we target this therapy?
The MDR[3][1] phenotype was developed by exposing cells to very high concentrations of cytotoxic agents in vitro [(1)][2] . The… 
1994
1994
The diagnostic value of multi-modality evoked potentials in Wilson's disease.
19 patients with a neurological manifestation of Wilson's disease (WD), most of them with long-term disease (> 10 yr), underwent… 
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