Skip to search formSkip to main contentSkip to account menu

ABCB11 gene

Known as: ABCB11, SPGP, ABC16 
This gene plays a role in the secretion of bile salts.
National Institutes of Health

Related topics

Related topics

6 relations
ABCB11 protein, humanATP HydrolysisHomo sapiensIonophore activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences
Objective— The mechanisms underlying the cardiovascular benefit of the anti-diabetic drug metformin are poorly understood. Recent… 
2016
2016
Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment
The bile salt export pump (BSEP) is expressed on the canalicular membrane of hepatocytes regulating liver bile salt excretion… 
2010
2010
Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes.
2010
2010
A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease.
Chronic HCV (hepatitis C virus)-associated cirrhosis represents a major indication for liver transplantation. Bile acids… 
Highly Cited
2006
Highly Cited
2006
High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis.
Human ATP-binding cassette transporter ABCB11 (SPGP/BSEP) mediates the elimination of bile salts from liver cells and thereby… 
2004
2004
Taurocholate transport by hepatic and intestinal bile acid transporters is independent of FIC1 overexpression in Madin–Darby canine kidney cells
Background:  Mutations in the human familial intrahepatic cholestasis gene, FIC1, result in progressive familial intrahepatic… 
2003
2003
Appearance of atypical 3α,6β,7β,12α-tetrahydroxy-5β-cholan-24-oic acid in spgp knockout mice Published, JLR Papers in Press, December 1, 2002. DOI 10.1194/jlr.M200394-JLR200
Bile formation and its canalicular secretion are essential functions of the mammalian liver. The sister-of-p-glycoprotein (spgp… 
Highly Cited
2002
Highly Cited
2002
Functional analysis of the rat bile salt export pump gene promoter.
The 5' flanking region of the bile salt export pump (Bsep) gene was systematically analysed to provide the basis for… 
2002
2002
Modulating multidrug resistance: can we target this therapy?
The MDR[3][1] phenotype was developed by exposing cells to very high concentrations of cytotoxic agents in vitro [(1)][2] . The… 
2000
2000
Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats.
The present study evaluates the roles of the multidrug resistance-1 P-glycoprotein, Mdr1a/1b, the bile salt export pump (Bsep… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)