Drug interactions between chemotherapeutic regimens and antiepileptics.
6‐Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase‐9 expression via blockade of nuclear factor‐κB activation
- H. Ling, H. Yang, S.H. Tan, W. Chui, E. Chew
- Biology, MedicineBritish Journal of Pharmacology
- 1 December 2010
The effects of shogaols against breast cancer cell invasion are assessed and the underlying mechanisms are investigated to investigate the underlying mechanism of antimetastatic activity.
Nanoparticulate Delivery System Targeted to Tumor Neovasculature for Combined Anticancer and Antiangiogenesis Therapy
Findings indicate that the targeted dual drug nanoparticulate delivery system encompassing both antiangiogenesis and anticancer effects can be a potential candidate in cancer therapy.
Building a successful platform for interprofessional education for health professions in an Asian university
A two-pronged approach was developed to ensure adequate coverage of key concepts relating to IPE within each involved faculty, and cross-faculty participation and progress within the IPE competency framework.
Integrin targeted drug and gene delivery
This review sheds light on the future development of integrin targeted drug and/or gene delivery systems and shows their potential as important pharmaceuticals in the near future.
Synthesis of pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors of thymidine phosphorylase.
An efficient and expeditious synthesis of di- and monosubstituted 2-aminoimidazoles.
A microwave-assisted protocol was developed for the construction of di- and monosubstituted 2-aminoimidazoles and significant rate enhancement was observed for both steps, and the overall reaction time was shortened to 20 min compared to 48 h of the conventional procedures.
Cancer informatics for the clinician: An interaction database for chemotherapy regimens and antiepileptic drugs
Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity.
- Fei-Fei Gan, Kamila K. Kaminska, Eng-Hui Chew
- Chemistry, BiologyAntioxidants and Redox Signaling
- 26 September 2013
Identification of Michael acceptor-centric pharmacophores among diversified compounds demonstrates that a systematic approach to discover and develop Michaelacceptor-based TrxR inhibitors is feasible.
Design of a Multifunctional PLGA Nanoparticulate Drug Delivery System: Evaluation of its Physicochemical Properties and Anticancer Activity to Malignant Cancer Cells
The developed multifunctional nanoparticles hold potential to treat malignant integrin-expressing cancers and showed high efficacy in inducing apoptosis in specific malignant cancer cell.