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Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.
BACKGROUND & AIMS Hepatic uptake of cholephilic organic compounds is mediated by members of the organic anion-transporting polypeptide (OATP) family. We aimed to characterize the novel OATP-B withExpand
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Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
The organic anion transporting polypeptides (rodents: Oatps, human: OATPs) form a superfamily of sodium-independent transport systems that mediate the transmembrane transport of a wide range ofExpand
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The superfamily of organic anion transporting polypeptides.
Organic anion transporting polypeptides (Oatps/OATPs) form a growing gene superfamily and mediate transport of a wide spectrum of amphipathic organic solutes. Different Oatps/OATPs have partiallyExpand
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Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain.
A novel multispecific organic anion transporting polypeptide (oatp2) has been isolated from rat brain. The cloned cDNA contains 3,640 bp. The coding region extends over 1,983 nucleotides, thusExpand
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St John's Wort induces intestinal P‐glycoprotein/MDR1 and intestinal and hepatic CYP3A4
St John's Wort (hypericum perforatum) is an herbal medicine that is frequently used for therapy of mild depression. Recently, St John's Wort was reported to substantially decrease blood/plasmaExpand
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The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions
During clinical trials bosentan, the first orally active endothelin receptor antagonist, caused asymptomatic transaminase elevations in some patients. In this study we investigated whether inhibitionExpand
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The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver*
Canalicular secretion of bile salts is a vital function of the vertebrate liver, yet the molecular identity of the involved ATP-dependent carrier protein has not been elucidated. We cloned theExpand
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Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin.
Microcystins are toxins produced by freshwater cyanobacteria. They are cyclic heptapeptides that exhibit hepato- and neurotoxicity. However, the transport systems that mediate uptake of microcystinsExpand
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Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver
The antibiotics rifamycin SV and rifampicin substantially reduce sulfobromophthalein (BSP) elimination in humans. In rats, rifamycin SV and rifampicin were shown to interfere with hepatic organicExpand
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Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier.
Organic anion-transporting polypeptides (Oatps) are a rapidly growing gene family of polyspecific membrane transporters. In rat brain, Oatp1 (gene symbol Slc21a1) and Oatp2 (Slc21a5) are localized atExpand
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