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Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.
It is concluded that P-glycoprotein limits the oral uptake of paclitaxel and mediates direct excretion of the drug from the systemic circulation into the intestinal lumen. Expand
Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3
While Oatp4 seems to work in concert with O atp1 and OatP2 in the basolateral membrane of rat hepatocytes, Oat p3 is a multispecific transport system in the small intestine. Expand
MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring.
The pharmacokinetic software package MW/Pharm offers an interactive, user-friendly program which gives rapid answers in clinical practice and performs the evaluation ofBioavailability studies, including various methods, and an extensive statistical evaluation of bioequivalence. Expand
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.
It is shown that posttranscriptional mechanisms play a more prominent role in LPS-induced regulation of human MRP2 and BSEP compared with the rat transporter proteins. Expand
Antiviral activities of lactoferrin.
An overview of the present knowledge about the antiviral activities of Lactoferrin is given and, when possible, the antiv viral modes of action of this protein are given. Expand
Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver.
It is concluded that endotoxin-induced cholestasis is caused by decreased mrp2 and spgp levels, as well as an abnormal localization of these proteins, which may confer resistance to hepatocytes against cytokine-induced metabolic stress. Expand
Dephosphorylation of endotoxin by alkaline phosphatase in vivo.
A crucial role is proposed for this enzyme in host defense during gram-negative bacterial infections and the localization of AP as an ecto-enzyme in most organs as well as the induction of enzyme activity during inflammatory reactions and cholestasis is in accordance with such a protective role. Expand
Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro.
Only native and conformationally intact lactoferrin from bovine or human milk, colostrum, or serum could completely block HCMV infection (IC50 = 35-100 micrograms/mL). Expand
Abstracts of papers
s of papers PARTICULATE SYSTEMS AS CARRIERS FOR SITE-SPECIFIC DRUG DELIVERY: THE STATE OF THE ART D.J.A. Crommelin In the last decade a number of particulate carrier systems have been developed toExpand
Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein
In vivo data demonstrate the in vivo contribution of intestinal P‐glycoprotein to direct elimination of [3H]‐digoxin from the systemic circulation and to the pattern of[3H], and they underline the importance of P‐ Glycoprotein for the blood‐brain barrier. Expand