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ATP-binding cassette transporters are powered by ATP, but the mechanism by which these transporters hydrolyze ATP is unclear. In… Expand The molecular chaperone heat-shock protein 90 (Hsp90) is one of the most abundant proteins in unstressed eukaryotic cells. Its… Expand The 26S proteasome degrades polyubiquitinated proteins by an energy-dependent mechanism. Here we define multiple roles for ATP in… Expand The Rad51 recombinase polymerizes on ssDNA to yield a right-handed nucleoprotein filament, called the presynaptic filament, that… Expand In cultured chick ciliary neurons, when ATP synthesis is inhibited, ATP depletion is reduced ∼50% by slowing actin filament… Expand A key goal in the study of the function of ATP-driven motor enzymes is to quantify the movement produced from consumption of one… Expand THE molecular chaperone proteins, particularly Hsp60 and Hsp70, have been implicated in essential cell functions under both… Expand Multidrug-resistant human tumor cells overexpress the MDR1 gene product P-glycoprotein, which is believed to function as an ATP… Expand This paper surveys several aspects of the consequences of ATP hydrolysis associated with actin polymerization, and their… Expand The hydrolysis of ATP by acto-HMM has been studied during the transient state using a rapid-mixing apparatus. The rate of… Expand