ABCB11 protein, human

Known as: ABC member 16, MDR-TAP subfamily protein, human, sister of P-glycoprotein protein, human, Bile Salt Export Pump 
Bile salt export pump (1321 aa, ~146 kDa) is encoded by the human ABCB11 gene. This protein plays a role in bile salt secretion.
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Intrahepatic cholestasis of pregnancy (ICP) has a complex aetiology with a significant genetic component. ABCB11… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND & AIMS Patients with severe bile salt export pump (BSEP) deficiency present as infants with progressive cholestatic… (More)
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Highly Cited
2006
Highly Cited
2006
Estrogens are known to cause hepatotoxicity such as intrahepatic cholestasis in susceptible women during pregnancy, after… (More)
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Highly Cited
2006
Highly Cited
2006
We determined the mechanisms of hepatobiliary injury in the lithocholic acid (LCA)-fed mouse, an increasingly used model of… (More)
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Highly Cited
2005
Highly Cited
2005
Pravastatin is a well known 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor. Cumulative studies have shown that pravastatin is… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND & AIMS Progressive familial intrahepatic cholestasis (PFIC) and benign recurrent intrahepatic cholestasis (BRIC) are… (More)
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Highly Cited
2004
Highly Cited
2004
Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder associated with increased risk of intrauterine fetal death and… (More)
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Highly Cited
2003
Highly Cited
2003
Endometriosis is clinically associated with pelvic pain and infertility, with implantation failure strongly suggested as an… (More)
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Highly Cited
2001
Highly Cited
2001
The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte… (More)
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Highly Cited
2000
Highly Cited
2000
We have previously shown that cloned rat multidrug resistance-associated protein 3 (Mrp3) has the ability to transport organic… (More)
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