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ABCB11 protein, human

Known as: ABC member 16, MDR-TAP subfamily protein, human, sister of P-glycoprotein protein, human, Bile Salt Export Pump 
Bile salt export pump (1321 aa, ~146 kDa) is encoded by the human ABCB11 gene. This protein plays a role in bile salt secretion.
National Institutes of Health

Related topics

Related topics

19 relations
ABCB11 geneATP HydrolysisAdenosine TriphosphatasesCellular Membrane

Broader (1)

ATP-Binding Cassette Transporters

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Differences in presentation and progression between severe FIC1 and BSEP deficiencies.
Highly Cited
2006
Highly Cited
2006
Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency
Hepatocellular carcinoma (HCC) is rare in young children. We attempted to see if immunohistochemical and mutational‐analysis… 
Highly Cited
2005
Highly Cited
2005
Bile Salt Export Pump (BSEP/ABCB11) Can Transport a Nonbile Acid Substrate, Pravastatin
Pravastatin is a well known 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor. Cumulative studies have shown that pravastatin is… 
Review
2004
Review
2004
The Complexities of Hepatic Drug Transport: Current Knowledge and Emerging Concepts
Recently, hepatic transport processes have been recognized as important determinants of drug disposition. Therefore, it is not… 
Highly Cited
2003
Highly Cited
2003
Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility.
Endometriosis is clinically associated with pelvic pain and infertility, with implantation failure strongly suggested as an… 
Highly Cited
2003
Highly Cited
2003
Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.
Highly Cited
2003
Highly Cited
2003
Guggulsterone Is a Farnesoid X Receptor Antagonist in Coactivator Association Assays but Acts to Enhance Transcription of Bile Salt Export Pump*
Guggulipid is an extract of the guggul treeCommiphora mukul and has been widely used to treat hyperlipidemia in humans. The plant… 
Highly Cited
2001
Highly Cited
2001
The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions
During clinical trials bosentan, the first orally active endothelin receptor antagonist, caused asymptomatic transaminase… 
Highly Cited
2000
Highly Cited
2000
ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)*
We have previously shown that cloned rat multidrug resistance-associated protein 3 (Mrp3) has the ability to transport organic… 
Highly Cited
2000
Highly Cited
2000
Expression of the bile salt export pump is maintained after chronic cholestasis in the rat.
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