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ABCB11 protein, human

Known as: ABC member 16, MDR-TAP subfamily protein, human, sister of P-glycoprotein protein, human, Bile Salt Export Pump 
Bile salt export pump (1321 aa, ~146 kDa) is encoded by the human ABCB11 gene. This protein plays a role in bile salt secretion.
National Institutes of Health

Related topics

Related topics

19 relations
ABCB11 geneATP HydrolysisAdenosine TriphosphatasesCellular Membrane

Broader (1)

ATP-Binding Cassette Transporters

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
A novel mutation within a transmembrane helix of the bile salt export pump (BSEP, ABCB11) with delayed development of cirrhosis
The bile salt export pump (BSEP, ABCB11) is essential for bile salt secretion at the canalicular membrane of liver cells… 
2010
2010
Transporter Studies with the 3-O-Sulfate Conjugate of 17α-Ethinylestradiol: Assessment of Human Liver Drug Transporters
17α-Ethinylestradiol (EE2), a component of oral contraceptives, is known to undergo considerable first-pass 3-O-sulfation in the… 
2009
2009
Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.
2007
2007
Effect of thiazolidinediones on bile acid transport in rat liver.
Highly Cited
2006
Highly Cited
2006
High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis.
Human ATP-binding cassette transporter ABCB11 (SPGP/BSEP) mediates the elimination of bile salts from liver cells and thereby… 
Highly Cited
2005
Highly Cited
2005
Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.
Prolonged administration of peroxisome proliferators to rodents typically leads to hepatocarcinogenesis. Peroxisome proliferator… 
Highly Cited
2004
Highly Cited
2004
Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase.
2004
2004
Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure.
Review
2002
Review
2002
Hepatobiliary transport of bile acids and organic anions.
Recent studies have elucidated the mechanism and regulation of hepatic transport of bile acids and organic anions. Bile acids are… 
Highly Cited
2000
Highly Cited
2000
MRP2, a human conjugate export pump, is present and transports fluo 3 into apical vacuoles of Hep G2 cells.
The multidrug resistance protein 2 (MRP2, symbol ABCC2) transports anionic conjugates and certain amphiphilic anions across the… 
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