Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.

@article{Hays2005RoleOP,
  title={Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.},
  author={Thomas Hays and Ivan Rusyn and Amanda M. Burns and Mary J. Kennett and Jerrold M Ward and Frank J. Gonzalez and Jeffrey M. Peters},
  journal={Carcinogenesis},
  year={2005},
  volume={26 1},
  pages={
          219-27
        }
}
Prolonged administration of peroxisome proliferators to rodents typically leads to hepatocarcinogenesis. Peroxisome proliferator-activated receptor-alpha (PPARalpha) is required to mediate alterations in PPARalpha target gene expression, repress apoptosis, enhance replicative DNA synthesis, oxidative stress to DNA and hepatocarcinogenesis induced by the relatively specific PPARalpha agonist, Wy-14,643. Interestingly, administration of the less specific PPARalpha agonist, bezafibrate, leads to a… CONTINUE READING
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