Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.
OATP-B is the third bromosulphophthalein uptake system localized at the basolateral membrane of human hepatocytes and is the first to be characterized with respect to tissue distribution and hepatocellular localization.
Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain.
- B. Noe, B. Hagenbuch, B. Stieger, P. Meier
- BiologyProceedings of the National Academy of Sciences…
- 16 September 1997
It is indicated that oatp2 may play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides from the body.
The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions
In this study, inhibition of the hepatocanalicular bile salt export pump (rodents, Bsep; humans, BSEP ABCB11) could account for bosentan‐induced liver injury.
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity,…
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver*
Results indicate that the sister of P-glycoprotein is the major canalicular bile salt export pump of mammalian liver.
Bosentan Is a Substrate of Human OATP1B1 and OATP1B3: Inhibition of Hepatic Uptake as the Common Mechanism of Its Interactions with Cyclosporin A, Rifampicin, and Sildenafil
- A. Treiber, R. Schneiter, Stephanie Häusler, B. Stieger
- Biology, ChemistryDrug Metabolism And Disposition
- 1 August 2007
Interactions with rifampicin, cyclosporin A, and, to a lesser extent, sildenafil represent evidence that inhibition of hepatic uptake may become the rate-limiting step in the overall elimination process even for drugs whose elimination is entirely dependent on metabolism.
The SLCO (former SLC21) superfamily of transporters.
Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver.
Bile salt transporters.
Transcriptional and posttranscriptional regulation of these enterohepatic bile salt transporters is closely related to the regulation of lipid and cholesterol homeostasis, which has been recognized as important causes for various cholestatic liver diseases.
Enterohepatic bile salt transporters in normal physiology and liver disease.
The vectorial transport of bile salts from blood into bile is essential for the generation of bile flow, solubilization of cholesterol in bile, and emulsification of lipids in the intestine. Major…