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ABCB1 wt Allele

Known as: ABC20, GP170, P-Glycoprotein Transporter C Allele 
Human ABCB1 wild-type allele is located in the vicinity of 7q21.1 and is approximately 210 kb in length. This allele, which encodes multidrug… 
National Institutes of Health

Related topics

Related topics

14 relations
7q21.1ABCB1 protein, humanCrohn DiseaseDrug Efflux

Broader (1)

ABCB1 gene

Papers overview

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Highly Cited
2012
Highly Cited
2012
Inhibition of COX-2 in colon cancer modulates tumor growth and MDR-1 expression to enhance tumor regression in therapy-refractory cancers in vivo.
Higher cyclooxygenase 2 (COX-2) expression is often observed in aggressive colorectal cancers (CRCs). Here, we attempt to examine… 
Highly Cited
2009
Highly Cited
2009
Combined Pharmacophore Modeling, Docking, and 3D QSAR Studies of ABCB1 and ABCC1 Transporter Inhibitors
Quinazolinones, indolo‐ and pyrrolopyrimidines with inhibitory effects toward ABCB1 (P‐gp) and ABCC1 (MRP1) transporters were… 
Highly Cited
2006
Highly Cited
2006
EXPRESSION AND FUNCTIONAL ACTIVITY OF BREAST CANCER RESISTANCE PROTEIN (BCRP, ABCG2) TRANSPORTER IN THE HUMAN CHORIOCARCINOMA CELL LINE BEWO
1 Breast cancer resistance protein (BCRP, ABCG2) is a drug efflux transporter that is believed to affect the drug disposition of… 
Highly Cited
2005
Highly Cited
2005
Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans
Highly Cited
2005
Highly Cited
2005
EXPRESSION AND FUNCTION OF ABCB1 AND ABCG2 IN HUMAN PLACENTAL TISSUE
The placenta plays an important role in modulating xenobiotic passage from mother to fetus. Studies in mice have demonstrated… 
Highly Cited
2005
Highly Cited
2005
Drug-Induced Regulation of the MDR1 Promoter in Candida albicans
ABSTRACT Resistance of Candida albicans to azole antifungal drugs is mediated by two types of efflux pumps, encoded by the MDR1… 
Review
2003
Review
2003
Vascular and parenchymal mechanisms in multiple drug resistance: a lesson from human epilepsy.
Long term treatment with antiepileptic drugs (AEDs) is the standard therapeutic approach to eradicate seizures. However, a small… 
Highly Cited
2000
Highly Cited
2000
Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined…
Mobilized peripheral blood progenitor cells (PBPC) are a potential target for the retrovirus-mediated transfer of cytostatic drug… 
Highly Cited
1994
Highly Cited
1994
P-glycoprotein, HER-2/neu, and mutant p53 expression in human gynecologic tumors.
BACKGROUND Overexpression of P-glycoprotein has been associated with a worse prognosis for some groups of patients not receiving… 
Highly Cited
1987
Highly Cited
1987
Localization of the human multiple drug resistance gene, MDR1, to 7q21.1
SummaryMultiple drug resistance has been shown to be associated with amplification/increased expression of a gene designated MDR… 
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