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Engaging neuroscience to advance translational research in brain barrier biology
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood–brain barrier (BBB)Expand
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Overexpression of Multiple Drug Resistance Genes in Endothelial Cells from Patients with Refractory Epilepsy
Summary:  Purpose: It has been suggested that altered drug permeability across the blood–brain barrier (BBB) may be involved in pharmacoresistance to antiepileptic drugs (AEDs). To test thisExpand
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Consequences of Repeated Blood-Brain Barrier Disruption in Football Players
The acknowledgement of risks for traumatic brain injury in American football players has prompted studies for sideline concussion diagnosis and testing for neurological deficits. While concussionsExpand
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  • Open Access
Persistent, Long-term Cerebral White Matter Changes after Sports-Related Repetitive Head Impacts
Introduction Repetitive head impacts (RHI) sustained in contact sports are thought to be necessary for the long-term development of chronic traumatic encephalopathy (CTE). Our objectives were to: 1)Expand
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Impaired K+ Homeostasis and Altered Electrophysiological Properties of Post-Traumatic Hippocampal Glia
Traumatic brain injury (TBI) can be associated with memory impairment, cognitive deficits, or seizures, all of which can reflect altered hippocampal function. Whereas previous studies have focused onExpand
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Seizure‐Promoting Effect of Blood–Brain Barrier Disruption
Summary:  Purpose: It is generally accepted that blood–brain barrier (BBB) failure occurs as a result of CNS diseases, including epilepsy. However, evidences also suggest that BBB failure may be anExpand
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Peripheral markers of blood-brain barrier damage.
Neurological diseases are often associated with cerebrovascular dysfunction and changes in blood-brain barrier (BBB) function. This is important for two seemingly conflicting reasons. On the oneExpand
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Serum S-100beta as a possible marker of blood-brain barrier disruption.
Two brain-specific proteins, S-100beta and neuron-specific enolase (NSE), are released systemically after cerebral lesions, but S-100beta levels sometimes rise in the absence of neuronal damage. WeExpand
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Functional Specialization and Topographic Segregation of Hippocampal Astrocytes
Astrocytes have been suggested to play several roles in the complex control of brain microenvironment. However, they have been generally considered to constitute a homogeneous population of cells.Expand
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Antagonism of peripheral inflammation reduces the severity of status epilepticus
Status epilepticus (SE) is one of the most serious manifestations of epilepsy. Systemic inflammation and damage of blood-brain barrier (BBB) are etiologic cofactors in the pathogenesis of pilocarpineExpand
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