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ABCB1 gene

Known as: ABC20, gene mdr1, GP170 
This gene plays a role in multi-drug resistance and is involved in blood-brain barrier transport.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Clopidogrel and prasugrel are subject to efflux via P-glycoprotein (encoded by ABCB1, also known as MDR1). ABCB1… Expand
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Review
2010
Review
2010
Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. P-glycoprotein is an important and the… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND A third of all kidneys from deceased donors in the UK are donated after cardiac death, but concerns have been raised… Expand
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Highly Cited
2005
Highly Cited
2005
Objectives ABCB1 (multidrug resistance 1 polypeptide, MDR1, Pgp) is a multispecific efflux transporter of drugs and xenobiotics… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND One third of patients with epilepsy have drug-resistant epilepsy, which is associated with an increased risk of death… Expand
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Highly Cited
2003
Highly Cited
2003
OBJECTIVES There is increasing evidence that polymorphism of the ABCB1 (MDR1) gene contributes to interindividual variability in… Expand
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Highly Cited
2001
Highly Cited
2001
Intestinal P-glycoprotein, which is encoded by the MDR1 gene, plays an important role in the absorption and presystemic… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND P-glycoprotein, the gene product of MDR1, confers multidrug resistance against antineoplastic agents but also plays an… Expand
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Highly Cited
2000
Highly Cited
2000
Two prominent members of the ATP-binding cassette superfamily of transmembrane proteins, multidrug resistance 1 (MDR1) P… Expand
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Highly Cited
1989
Highly Cited
1989
Many cancers have been cured by chemotherapeutic agents. However, other cancers are intrinsically drug resistant, and some… Expand
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