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ABCB1 protein, human

Known as: p-glycoprotein, MDR1 protein, human, ATP-Binding Cassette Sub-Family B Member 1 
Multidrug resistance protein 1 (1280 aa, ~141 kDa) is encoded by the human ABCB1 gene. This protein plays a role in both ATP-dependent transport of… 
National Institutes of Health

Related topics

Related topics

23 relations
ABCB1 geneABCB1 wt AlleleAdenosine TriphosphatasesBlood - brain barrier anatomy

Broader (2)

P-GlycoproteinP-Glycoproteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Methyl-cyclopentadienyl Ruthenium Compounds with 2,2'-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential.
New ruthenium methyl-cyclopentadienyl compounds bearing bipyridine derivatives with the general formula [Ru(η5-MeCp)(PPh3)(4,4'-R… 
2010
2010
Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O6-methylguanine-DNA methyltransferaseP140K
Myelotoxicity is a dose-limiting effect of many chemotherapeutic regimens. Thus, there is great interest in protecting human… 
2009
2009
Telmisartan pharmacokinetics in Japanese renal transplant recipients.
Highly Cited
2005
Highly Cited
2005
EXPRESSION AND FUNCTION OF ABCB1 AND ABCG2 IN HUMAN PLACENTAL TISSUE
The placenta plays an important role in modulating xenobiotic passage from mother to fetus. Studies in mice have demonstrated… 
2004
2004
Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow.
2004
2004
Tacrolimus Therapy According to Mucosal MDR1 Levels in Small‐bowel Transplant Recipients
2003
2003
Simultaneous genotyping of seven single-nucleotide polymorphisms in the MDR1 gene by single-tube multiplex minisequencing.
Responses to different drugs can vary widely among different individuals as a result of genetic variations in drug-metabolizing… 
Highly Cited
2001
Highly Cited
2001
Identification of an Amino Acid Residue in Multidrug Resistance Protein 1 Critical for Conferring Resistance to Anthracyclines*
Murine multidrug resistance protein 1 (mrp1), unlike human MRP1, does not confer resistance to anthracyclines. Previously, we… 
2001
2001
Expression of multidrug resistance 1 and glutathione-S-transferase-Pi protein in nasopharyngeal carcinoma.
Radiotherapy is the modality of choice for the treatment of nasopharyngeal carcinoma (NPC). However, systemic chemotherapy has… 
Highly Cited
1994
Highly Cited
1994
Cellular control of human multidrug resistance 1 (mdr-1) gene expression in absence and presence of gene amplification in human cancer cells.
The Kst-6 cell line is a human KB carcinoma cell line that has a stably integrated chloramphenicol acetyl-transferase (CAT… 
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