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ABCB1 protein, human

Known as: p-glycoprotein, MDR1 protein, human, ATP-Binding Cassette Sub-Family B Member 1 
Multidrug resistance protein 1 (1280 aa, ~141 kDa) is encoded by the human ABCB1 gene. This protein plays a role in both ATP-dependent transport of… 
National Institutes of Health

Related topics

Related topics

23 relations
ABCB1 geneABCB1 wt AlleleAdenosine TriphosphatasesBlood - brain barrier anatomy

Broader (2)

P-GlycoproteinP-Glycoproteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
(R)-[11C]verapamil is selectively transported by murine and human P-glycoprotein at the blood–brain barrier, and not by MRP1 and BCRP
Highly Cited
2012
Highly Cited
2012
Let‐7 modulates acquired resistance of ovarian cancer to Taxanes via IMP‐1‐mediated stabilization of multidrug resistance 1
Ovarian cancer patients frequently develop resistance to chemotherapy regiments using Taxol and carboplatin. One of the… 
Highly Cited
2011
Highly Cited
2011
Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.
Sildenafil is a potent and selective inhibitor of the type 5 cGMP (cyclic guanosine 3',5'-monophosphate)-specific… 
Review
2008
Review
2008
Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs.
As the importance of drug transporters in the clinical pharmacokinetics of drugs is recognized, genetic polymorphisms of drug… 
Highly Cited
2005
Highly Cited
2005
Clinical role of multidrug resistance protein 1 expression in chemotherapy resistance in early-stage breast cancer: the Austrian Breast and Colorectal Cancer Study Group.
PURPOSE The multidrug resistance protein 1 (MRP1) is expressed in human breast cancer cells and may contribute to the clinical… 
Highly Cited
2003
Highly Cited
2003
Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).
In tumor cells, the human multidrug resistance protein 1 (MRP1), confers resistance to a broad spectrum of anticancer agents… 
Highly Cited
2003
Highly Cited
2003
Expression profiles of drug-metabolizing enzyme CYP3A and drug efflux transporter multidrug resistance 1 subfamily mRNAS in small intestine.
The purpose of this study is to examine the expression profiles of CYP3A1, CYP3A2, CYP3A9, and CYP3A18 mRNAs as well as multidrug… 
Highly Cited
2001
Highly Cited
2001
Expression of Multidrug Resistance‐related Transporters in Human Breast Carcinoma
The expression levels of mRNA for multidrug resistance 1 (MDR1) gene, multidrug resistance protein 1 (MRP1), lung resistance… 
Highly Cited
1998
Highly Cited
1998
Direct Involvement of the Y-box Binding Protein YB-1 in Genotoxic Stress-induced Activation of the Human Multidrug Resistance 1 Gene*
The human multidrug resistance 1 (MDR1) gene encoding P-glycoprotein is often overexpressed in various human tumors after… 
Highly Cited
1993
Highly Cited
1993
Enhanced expression of the human multidrug resistance 1 gene in response to UV light irradiation.
The multidrug resistance 1 (MDR1) gene encodes a M(r) 170,000 membrane glycoprotein termed P-glycoprotein, which catalyzes the… 
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