ABCB1 protein, human

Known as: p-glycoprotein, MDR1 protein, human, ATP-Binding Cassette Sub-Family B Member 1 
Multidrug resistance protein 1 (1280 aa, ~141 kDa) is encoded by the human ABCB1 gene. This protein plays a role in both ATP-dependent transport of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
010203019902017

Papers overview

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Highly Cited
2014
Highly Cited
2014
Triple negative breast cancers (TNBCs) are defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human… (More)
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2014
2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner… (More)
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2012
2012
Ovarian cancer patients frequently develop resistance to chemotherapy regiments using Taxol and carboplatin. One of the… (More)
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2011
2011
Cynomolgus monkey has been used as a model for the prediction of drug disposition in human brain. The purpose of this study was… (More)
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2008
2008
OBJECTIVE The potential influence of the multidrug resistance 1 (MDR1) gene and the cytochrome P450 (CYP) genes, CYP3A4 and… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND A significant number of patients treated with anthracyclines develop cardiotoxicity (anthracycline-induced… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND & AIMS The human multidrug resistance 1 (MDR1) gene product P-glycoprotein is highly expressed in intestinal… (More)
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Highly Cited
2001
Highly Cited
2001
Cytochrome P450 enzymes metabolize various endogenous and exogenous small molecular weight compounds. Transport-associated… (More)
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Highly Cited
1998
Highly Cited
1998
The human multidrug resistance 1 (MDR1) gene encoding P-glycoprotein is often overexpressed in various human tumors after… (More)
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Highly Cited
1998
Highly Cited
1998
Chromosomal translocations in acute leukemia that affect the AML-1/CBFbeta transcription factor complex create dominant… (More)
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