P-Glycoproteins

Known as: P-Glycoproteins [Chemical/Ingredient], Multidrug Resistance Proteins, p-glycoprotein 
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P… (More)
National Institutes of Health

Papers overview

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Review
2008
Review
2008
P-glycoprotein (P-gp, ABCB1, MDR1) was recognized as a drug-exporting protein from cancer cells three decade ago. Apart from the… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Numerous knockout mouse studies have revealed that P-glycoprotein (P-gp) significantly limits drug distribution across… (More)
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Highly Cited
2003
Highly Cited
2003
Overexpression of P-glycoprotein (P-gp), the MDR1 gene product, confers multidrug resistance (MDR) to cancer cells. Clinically… (More)
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Highly Cited
2000
Highly Cited
2000
The human multidrug resistance-1 (MDR1) gene product, P-glycoprotein (P-gp), is well known for its ability to confer drug… (More)
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Highly Cited
1999
Highly Cited
1999
The blood-brain barrier is a major impediment to the entry of many therapeutic drugs into the brain. P-Glycoprotein is an ATP… (More)
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Highly Cited
1999
Highly Cited
1999
Therapeutic resistance is a major obstacle in the treatment of acute myeloid leukemia (AML). Such resistance has been associated… (More)
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Highly Cited
1999
Highly Cited
1999
Fexofenadine, a nonsedating antihistamine, does not undergo significant metabolic biotransformation. Accordingly, it was… (More)
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Highly Cited
1999
Highly Cited
1999
PURPOSE To investigate whether d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) functions as an inhibitor of P… (More)
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Highly Cited
1999
Highly Cited
1999
It was recently shown that naturally occurring Mdr1a mutant fetuses of the CF-1 outbred mouse stock have no placental Mdr1a P… (More)
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Highly Cited
1997
Highly Cited
1997
In this paper, we show that P-glycoprotein contains two distinct sites for drug binding and transport, and that, unexpectedly… (More)
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