Skip to search formSkip to main contentSkip to account menu

P-Glycoproteins

Known as: P-Glycoproteins [Chemical/Ingredient], Multidrug Resistance Proteins, p-glycoprotein 
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P… 
National Institutes of Health

Related topics

Related topics

23 relations
ABCB1 geneIn BloodMulti-Drug ResistanceMultidrug Resistance Gene

Narrower (8)

ABCB1 protein, humanCholestasis, progressive familial intrahepatic 3P-glycoprotein 2PGP-2 protein, C elegans

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Combined Pharmacophore Modeling, Docking, and 3D QSAR Studies of ABCB1 and ABCC1 Transporter Inhibitors
Quinazolinones, indolo‐ and pyrrolopyrimidines with inhibitory effects toward ABCB1 (P‐gp) and ABCC1 (MRP1) transporters were… 
Highly Cited
2006
Highly Cited
2006
Expression of the multidrug resistance P-glycoprotein, (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation.
Review
2004
Review
2004
Defining pathways of loss and secretion of chemical messengers from astrocytes
It is becoming evident that glia, and astrocytes in particular, are intimately involved in neuronal signaling. Astrocytic… 
Review
2002
Review
2002
Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein.
The pharmacological effects of a drug are highly dependent on the absorption, metabolism, elimination, and distribution of the… 
Highly Cited
2000
Highly Cited
2000
Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance.
OC144-093 is a novel substituted diarylimidazole (Mr 495) generated using the OntoBLOCK system, a solid-phase combinatorial… 
Review
1998
Review
1998
Pharmacological insights from P-glycoprotein knockout mice.
The mdr1-type P-glycoproteins can confer multidrug resistance to tumor cells by actively pumping a wide variety of drugs from the… 
Highly Cited
1994
Highly Cited
1994
Functional expression of P-glycoproteins in secretory vesicles.
We expressed P-glycoproteins (P-gps) encoded by the three mouse mdr genes in the membranes of secretory vesicles (SV… 
Review
1991
Review
1991
Multidrug resistance mediated by P-glycoproteins.
Overexpression of P-glycoprotein genes is a well-established cause of one form of multidrug resistance. P-glycoproteins are… 
Highly Cited
1990
Highly Cited
1990
Expression of P-glycoprotein in adult T-cell leukemia cells.
We have examined the expression of P-glycoprotein (P-gp) in adult T-cell leukemia (ATL) samples from 25 patients. Based on… 
Highly Cited
1988
Highly Cited
1988
Mechanisms of multidrug resistance in HL60 cells: evidence that a surface membrane protein distinct from P-glycoprotein contributes to reduced cellular accumulation of drug.
HL60 cells exhibiting a 140-fold increase in resistance to vincristine contain three surface membrane proteins with molecular… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)